Boston University CCCR

总体来说 摘要 波士顿大学CCCR将作为临床研究的中心资源，主要集中在 常见的肌肉骨骼疾病，骨关节炎和痛风，也将提供研究资源 硬皮病、脊椎关节炎、肌肉骨骼疼痛和骨质疏松症的研究者研究。中心 赠款基金每年在同行评议的期刊上发表30-35篇论文，其中大多数是主要的关节炎 一些期刊和一些领先的普通医学期刊。这个中心培养了许多领先的临床医生 风湿学的研究人员在美国和国际上，这些前学员中的许多人 与该中心积极合作。 我们将在这个CCCR中包括一个广泛的研究社区和一个核心的教员团队。研究界的 随时可以接触到核心教员以及他们提供的复杂研究方法和帮助，这将增强 社区的临床和转译研究，并将增加核心的合作机会 教职员工和社区。CCCR更新了BU对流行病学方法的历史关注，将新的 因果推理的方法，并增加了机器学习和移动健康的新方法。 研究和评价支持核心单位(RESCU)是本CCCR的重点。一个关键功能是 每周研究(RESCU会议，对正在进行的和拟议的研究项目进行严格评估。 这一功能确保了临床医生研究人员、流行病学家和生物统计学家之间的频繁互动 谁是CCCR的核心成员。RESCU核心单位为其他中心提供了关键支持 波士顿大学与风湿性和关节炎相关的助学金，三名现任R01/U01‘S；五名现任美国国立卫生研究院 K奖项(1个K24，3个K23‘S，1个K01)，1个R03，1个NIH试验规划补助金(U34)，以及多个ACR RRF奖项。 该中心的总体目标是开展和传播国家通报的高水平临床研究 的艺术临床研究方法和临床和生物科学的发现。最终，我们的目标是 为了预防我们正在研究的疾病，或者改善那些患有这种疾病的人的生活。

OVERALL ABSTRACT The Boston University CCCR will serve as a central resource for clinical research focused mostly on the most common musculoskeletal disorders, osteoarthritis and gout and will also provide research resources for investigator based research in scleroderma, spondyloarthritis, musculoskeletal pain and osteoporosis. Center grant funding has supported 30-35 papers annually in peer reviewed journals, most in the leading arthritis journals and some in leading general medical journals. This center has trained many of the leading clinical researchers in rheumatology throughout the US and internationally, and many of these former trainees have active collaborations with the center. We will include a broad research community and a core group of faculty in this CCCR. The research community's ready access to core faculty and to the sophisticated research methods and assistance they provide will enhance the clinical and translational research of the community and will increase collaborative opportunities for the core faculty and the community. The CCCR updates BU's historical focus on epidemiologic methods to include new approaches to causal inference and adds new methods in machine learning and mobile health. The Research and Evaluation Support Core Unit (RESCU) is the focal point of this CCCR. A key feature is the weekly research (RESCU meetings in which ongoing and proposed research projects are critically evaluated. This feature ensures frequent interactions between clinician researchers, epidemiologists and biostatisticians who are the core members of the CCCR. The RESCU core unit has provided critical support for other Center grants related to rheumatic and arthritic disorders at Boston University, three current R01/U01's; five current NIH K awards (one K24, 3 K23's, one K01), an R03, an NIH trial planning grant (U34), and multiple ACR RRF awards. The overall goal of this center is to carry out and disseminate high-level clinical research informed both by state of the art clinical research methods and by clinical and biological scientific discoveries. Ultimately, we aim either to prevent the diseases we are studying or to improve the lives of those living with the diseases.