NEI Center Core Grant for Vision Research

整体核心项目摘要 科尔眼科研究所(CEI)视力研究核心设施的总体目标是促进对结构的分析， 通过对共享资源进行集中评估来影响视觉系统的功能和疾病机制。《核心》 设施将提供资源、专业知识和设备，以帮助一个充满活力和高度 克利夫兰临床基金会CEI视觉科学研究人员协作组。中国的长期目标是 这笔赠款为研究人员提供的服务是预防早产儿视网膜病变等疾病的失明和恢复视力， 糖尿病视网膜病变。AMD和遗传性视网膜变性。为此，我们开发了一系列核心模块 这将继续提供视觉研究所需的最先进的仪器和技术。三个核心 模块包括：(1)视觉成像核心；(2)功能视觉核心；(3)分子信息学核心。这些核心包含 由经验丰富的研究科学家监督的高技能技术人员维护和操作的设备。 将这些技术整合到三个核心中，使我们能够将这些技术和技能带给 我们的计划，我们预计将继续提高用户实验室的生产力，并避免重复 装备和努力。这三个核心的成功运行将为每个NEI带来这些技术中的最好 RO1支持该机构的实验室。我们还设想，这些核心模块将继续增强和维持 协作的科学环境是CEI Vision研究小组的一个重要特征。这些核心还将 与上一个赠款周期一样，提高参与调查人员的工作效率，并允许初级调查人员 能够获得有助于生成支持新RO1应用的初步数据的服务和研究策略。

Overall Core Project Summary The overall aim of the Cole Eye Institute (CEI) Core Facilities for Vision Research is to facilitate the analysis of the structure, function and disease mechanisms that affect the visual system by providing centralized assess to shared resources. The Core Facilities will provide resources, expertise and equipment to aid in the research endeavors of a vibrant and highly collaborative group of vision science investigators at CEI of the Cleveland Clinic Foundation. The long-term goal of the investigators served by this grant is to prevent blindness and restore vision in diseases such as Retinopathy of Prematurity, Diabetic Retinopathy. AMD and Inherited Retinal Degenerations. To this end we have developed a series of Core modules that will continue to provide state-of-the-art instrumentation and technologies required for vision research. The three Core modules are: (1) Ocular Imaging Core; (2) Functional Vision Core; and (3) Molecular Informatics Core. These Cores contain equipment that is maintained and operated by highly skilled technicians that are supervised by established research scientists. Consolidating these technologies into the three Cores allows us to bring these techniques and skills to all potential users in our program, which we anticipate will continue to increase productivity in the user laboratories and avoid duplication of equipment and effort. Successful operation of these three Cores will bring the best of these technologies to each of the NEI RO1 supported laboratories in this institution. We also envision that these Core modules will continue to enhance and sustain the collaborative scientific environment that is a strong feature of the CEI Vision research group. The Cores will also enhance productivity among the participating investigators as in the previous grant cycle and allow junior investigators to have access to services and research strategies that will help generate preliminary data to support new RO1 applications.