Core Facilities for Vision Research

项目总结/摘要 哥伦比亚大学有一个由国家眼支持的大型和充满活力的视觉研究社区 研究所，共有25名合格的R 01赠款和48名视觉科学家。哥伦比亚靶场的视觉研究 从果蝇和小鼠视网膜和视觉脑发育的遗传研究， 人类视网膜疾病的研究。计算，神经生理，光学显微镜，遗传， 生物化学和临床技术集中在一系列问题上，包括眼睛的发育， 视觉脑，眼血管生成机制，视觉和眼神经系统科学 行为，病理生理学，遗传学，以及视网膜疾病如黄斑变性的治疗， 视网膜色素变性、近视和青光眼。为了支持这项视觉研究，我们正在申请更新我们的 国家眼科研究所拨款P30 EY 019007，将继续支持一套视觉核心设施 研究并提供个人研究赠款无法提供的服务。补助金支持 三个研究核心：i）仪器制造和设计核心，设计和建造定制的 ii）一个计算机核心，为数百台计算机提供支持和维护， 包括视觉研究界使用的实时实验室计算机接口， 研究专用数据库设计，集成数据存储，管理和分析与新基因组学 分析套件;和iii）成像、组织学和功能诊断核心，其提供组织学， 活体、荧光显微镜、OCT和ERG服务。这笔赠款不仅支持目前资助的 研究人员与NEI R 01，但也援助视觉科学家的工作，由其他NEI基金支持 机制，其他NIH研究所，重要的是，年轻的研究人员收集数据，以提交他们的研究报告。 第一批NEI赠款。这项资助促进了哥伦比亚视觉研究中心成员之间的合作 社区，并鼓励目前没有从事视觉研究的科学家利用他们的专业知识， 与视力有关的问题。

Project Summary/Abstract Columbia University has a large and vibrant vision research community supported by the National Eye Institute, with 25 qualifying R01 grants and 48 vision scientists in all. Vision research at Columbia ranges across a gamut of topics, from genetic studies of retinal and visual brain development in Drosophila and mice to studies of human retinal disease. Computational, neurophysiological, light microscopic, genetic, biochemical, and clinical techniques focus on a range of problems including the development of the eye and the visual brain, the mechanisms of ocular angiogenesis, the systems neuroscience of visual and oculomotor behavior, and the pathophysiology, genetics, and treatment of retinal diseases such as macular degeneration, retinitis pigmentosa, myopia, and glaucoma. To support this vision research, we are applying to renew our National Eye Institute grant P30 EY019007, which will continue to support a set of Core Facilities for Vision Research and enable services that could not be provided by individual research grants. The grant supports three research cores: i) an Instrumentation Fabrication and Design Core that designs and builds custom equipment; ii) a Computer Core that performs support and maintenance for the hundreds of computers, including real-time laboratory computer-based interface used by the vision research community, handles research-specific database design, integrated data storage, management and analysis with the new Genomics Analysis Suite; and iii) an Imaging, Histology and Functional Diagnostics Core, which provides histological, in vivo, fluorescent microscopy, OCT, and ERG services. The grant not only supports currently funded investigators with NEI R01s, but also aids the work of vision scientists supported by other NEI funding mechanisms, other NIH institutes, and, importantly, young investigators gathering data in order to submit their first NEI grants. This grant facilitates collaboration among members of the Columbia vision research community, and encourages scientists not currently engaged in vision research to use their expertise in problems related to vision.