Quantitative Sciences Core

项目概要-定量科学核心 定量科学（QS）核心通过将早期阶段和 建立了艾滋病毒/艾滋病调查人员，他们具有深思熟虑地设计实验所需的分析专业知识， 使用严格的统计方法进行研究，并酌情使用最先进的统计方法， 生物信息学或计算生物学方法来剖析复杂的数据集。前身为 生物统计学和计算核心，新名称反映了为生物统计学和计算核心提出的服务范围的扩大。 下一个资金周期，现在包括生物统计学，计算生物学，基因组学和微生物 生物信息学和人口健康分析。QS核心有四个具体目标：1）提供咨询， 分析和赠款支持服务; 2）提供定量方法的教育和指导; 3）开发 艾滋病毒/艾滋病研究的创新方法;以及4）促进内部、CFAR内部、CFAR之间和外部 合作。QS Core的首要任务是提供有用的统计和分析资源和服务 CFAR社区。为了实现这一目标，QS核心将继续提供临时咨询和步行- 在诊所，对手稿进行统计分析，并合作准备赠款提案。在 特别是，核心小组确保早期调查人员得到充分的指导、培训和分析， 支持.在这个资助周期中，我们将为所有CFAR试点赠款获奖者提供免费的数据分析支持， 这将直接有助于他们取得成功。通过杜克的附属定量核心 癌症研究所、全球健康研究所、临床和转化科学研究所和儿童 健康和发展倡议，CFAR调查人员现在将有机会获得更广泛的专业知识， 一系列定量领域，包括药物基因组学和电子健康记录。QS核心将 通过数据分析方面的年度讲习班和合作项目提供教育和指导， 将生物统计学研究生与CFAR调查员配对。此外，QS Core还将提供 艾滋病毒/艾滋病研究定量方法的综合研究教育计划，包括 暑期实习以及数据科学，统计学和复杂分析的研讨会。的 QS Core通过以下方式寻求创新：（1）开发新的培训和教育机会，例如无预约诊所 和各种研讨会;和（2）与CFAR核心和/或 调查人员提高数据来源和统计的严谨性。最后，QS核心广泛合作， 与杜克CFAR的其他核心和科学工作组（SWG）合作;有多个联合项目 与临床、发展和免疫学核心以及北卡罗来纳州大学合作， 查佩尔山CFAR生物统计核心，并与艾滋病毒/艾滋病研究人员在南卡罗来纳州大学谁 没有状态CFAR。

PROJECT SUMMARY – Quantitative Sciences Core The Quantitative Sciences (QS) Core enhances HIV/AIDS research at Duke by linking early stage and established HIV/AIDs investigators with the analytic expertise needed to thoughtfully design experiments, conduct research using statistically rigorous approaches, and where appropriate, use state-of-the-art statistical, bioinformatics, or computational biology methods to dissect complex data sets. Formerly known as the Biostatistics and Computational Core, the new name reflects the expanded range of services proposed for the next funding cycle, now encompassing biostatistics, computational biology, genomics and microbial bioinformatics, and population health analysis. The QS Core has four Specific Aims: 1) Provide consultation, analysis, and grant support services; 2) Provide education and mentoring in quantitative methods; 3) Develop innovative methods in HIV/AIDS research; and 4) Foster internal, intra-CFAR, inter-CFAR, and external collaborations. The QS Core's top priority is to provide useful statistical and analytical resources and services to the CFAR community. To accomplish this, the QS Core will continue to offer ad hoc consultations and walk- in clinics, conduct statistical analyses for manuscripts, and collaborate in the preparation of grant proposals. In particular, the Core ensures that early stage investigators receive adequate mentoring, training, and analytic support. In this funding cycle, we will provide free data analysis support for all CFAR Pilot Grant awardees, which will contribute directly to their successful outcomes. Through affiliated quantitative cores from the Duke Cancer Institute, Global Health Research Institute, Clinical and Translational Sciences Institute, and Child Health and Development Initiative, CFAR investigators will now have access to expertise in a much wider range of quantitative fields, including Pharmacogenomics and Electronic Health Records. The QS Core will provide education and mentoring through annual workshops in data analysis, and collaborative projects that pair biostatistics graduate students with CFAR investigators. Additionally, the QS Core will offer a comprehensive research education program in quantitative methods for HIV/AIDS research that includes summer internships as well as workshops in data science, statistics, and the analysis of complex assays. The QS Core seeks innovation by (1) developing new training and education opportunities, such as walk-in clinics and a variety of workshops; and (2) methods development in collaboration with CFAR Cores and/or investigators to improve data provenance and statistical rigor. Lastly, the QS Core collaborates extensively with other Cores and Scientific Working Groups (SWGs) in the Duke CFAR; there are multiple joint projects with the Clinical, Development, and Immunology Cores, as well as with the University of North Carolina at Chapel Hill CFAR Biostatistics Core, and with HIV/AIDS researchers at the University of South Carolina who do not have an in-state CFAR.