CSHL 2023 Eukaryotic DNA Replication and Genome Maintenance Conference

2023年CSHL真核DNA复制与基因组维护会议 项目总结/摘要 本次会议将是第19届真核DNA复制和基因组两年一度的会议 维护和遵循在冷泉港每隔一段时间举行的非常成功的会议 自1987年9月以来。这是唯一定期举行的会议，专门集中在真核生物 DNA复制。由于这一重点，会议在我们的快速增长中发挥了重要作用。 了解真核DNA复制过程以及它如何整合到细胞分裂周期中。这 今年的会议将专门讨论与染色体复制，结构， 和功能，并将包括在细胞周期和生长控制领域的生物学研究的重要领域， 基因组扩增和复制装置对DNA损伤的反应。随着磁场的移动 在过去的十年里，我们越来越重视DNA复制在生物学中的核心作用。 DNA损伤和复制应激反应，以及细胞用于最小化基因组威胁的策略 由DNA复制产生的完整性。DNA复制和DNA损伤反应的快速收敛 菲尔兹使这次会议很及时。会议的形式将确保传达最近的成果 并进行面对面的讨论，这将促进进展和合作。青年的参与 研究人员、少数民族和女科学家受到大力鼓励。 2023年的会议将包括一系列不同的主题，系统和方法，包括研究 在细菌、酵母、果蝇、非洲爪蟾等多种生物体中的染色体复制和基因扩增 和哺乳动物细胞。会议将涵盖（1）细胞周期中的复制起源控制;（2）发育 DNA复制和复制时间的控制;（3）染色质和基因组/核结构;（4） 复制叉停滞、稳定和检查点激活;（5）复制起始因子和起源 激活;（6）复制偶联基因组不稳定性，癌症和疾病（7） 复制应激;（8）分叉进展和终止。不受控制的DNA复制是肿瘤的标志 DNA复制中的错误导致基因组的不稳定性，而染色体复制的过程是一个主要的 化疗和放疗靶点。这次会议对癌症研究的相关性，并最终改善 治疗，不能过分强调。 DNA的复制是所有（真核）生命的基本过程。本次会议将重点讨论 了解这一过程发生的机制，以及DNA复制如何有助于基因组 稳定性，维持细胞的表观遗传状态，以及该过程的失调如何有助于 疾病，尤其是癌症。这次会议的知识价值包括领导的机会， 在他们的科学生涯的各个阶段的研究人员分享和讨论他们的最新成果和概念。的 在口头和海报会议上进行的非正式同行审查在提供快速反馈方面非常宝贵， 加速未来的研究。这次会议还提供了充分的机会，学习和建设 合作。我们不计划在时间表内并行会议，以便所有与会者共享一个共同的 与世隔绝的场地最大限度地提高了富有成效的科学交流的可能性。 大型、成熟的会议通常会产生重大影响，而这次冷泉会议 无疑推动了DNA复制的研究。这次会议的独特之处， 广泛的影响是年轻科学家的积极参与，他们将特别受益于这个机会。 展示他们最新的想法会议档案（可通过互联网访问的领先视频档案） 允许与会者与无法参加会议的同事分享会议的各个方面， 保护提交作者提交未发表研究的权利。

2023 CSHL CONFERENCE ON EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE PROJECT SUMMARY/ABSTRACT This conference will be the 19th biennial meeting on Eukaryotic DNA Replication and Genome Maintenance and follows the highly successful meetings that have been held at Cold Spring Harbor every other year since September 1987. It is the only regularly occurring meeting that is exclusively focused on eukaryotic DNA replication. Because of this focus, the meeting has played a major role in the rapid growth in our understanding of the eukaryotic DNA replication process and how it is integrated into the cell division cycle. This year’s conference will be devoted to fundamental research topics related to chromosome duplication, structure and function, and will include important areas of biological research in the areas of cell cycle and growth control, genomic amplification, and the response of the replication apparatus to DNA damage. As the field has moved forward over the past decade, we have placed an increased emphasis on the central role of DNA replication in the DNA damage and replication stress response, and strategies used by cells to minimize threats to genomic integrity arising from DNA replication. The rapid convergence of the DNA replication and DNA damage response fields makes this a timely meeting. The format of the meeting will ensure that recent results are communicated and discussed face-to-face, which will enhance progress and collaboration. The participation of young investigators, minority, and women scientists is strongly encouraged. The 2023 meeting will include a diverse array of topics, systems, and approaches including studies of chromosomal replication and gene amplification in organisms as diverse as bacteria, yeast, Drosophila, Xenopus and mammalian cells. Sessions will cover (1) Replication Origin Control in the Cell Cycle; (2) Developmental Control of DNA Replication and Replication Timing; (3) Chromatin and Genome/Nuclear Architecture; (4) Replication Fork Stalling, Stabilization and Checkpoint Activation; (5) Replication Initiation Factors and Origin Activation; (6) Replication-Coupled Genome Instability, Cancer and Disease (7) Causes and Consequences of Replication Stress; (8) Fork Progression and Termination. Uncontrolled DNA replication is a hallmark of tumors and errors in DNA replication lead to genomic instability, while the process of chromosome replication is a major target for chemo- and radiotherapy. The relevance of this meeting to cancer research, and ultimately to improved therapies, cannot be overemphasized. Replication of DNA is a fundamental process in all (eukaryotic) life. This meeting will focus on understanding the mechanism by which this process occurs, and how DNA replication contributes to genome stability, maintenance of the epigenetic state of a cell and how misregulation of this process contributes to diseases, most notably, cancer. The intellectual merits of this conference include the opportunity for leading investigators at all stages of their scientific careers to share and discuss their latest results and concepts. The informal peer review in oral and poster sessions is invaluable in providing rapid feedback that will fruitfully steer and accelerate future research. This conference also provides ample opportunity for learning and for building collaborations. We do not plan parallel sessions within the schedule so that all attendees share a common experience, while the secluded venue maximizes the likelihood of productive scientific exchange. Large, established conferences generally can have significant impact, and this Cold Spring meeting has undoubtedly driven forward research in DNA replication. Unique aspects of this conference that have particularly broad impact are the active participation of younger scientists who will particularly benefit from the opportunity to present their latest ideas. The conference archive (Leading strand video archive accessible by the internet) allows participants to share aspects of the conference with their colleagues who were unable to attend while protecting the right of the presenting authors to present unpublished research.