Core 04: Pilot Projects Program

项目摘要：试点项目计划核心 试点项目方案(PPP)核心的目标是增加在以下领域培训的初级调查人员数量 临床和转化性研究与成熟的资深科学家团队合作，开发创新 路易斯安那州解决慢性病负担的研究计划。这对我们的 鉴于存在严重的健康差距，该区域的卫生保健工作取得了显著进展。为了实现这一目标，PPP核心提供了直接和重要的 对试点项目的财政支持，使这些项目能够利用其他核心的专门知识和资源， 促进跨合作机构的实物支持，并促进教育和培训，以提高每个机构 获奖者作为一名独立翻译调查员的长期成功。虽然目前的供资周期是 由于COVID具有挑战性，PPP资助了各机构的36个试点项目，其中包括3个多项目 机构、多名研究人员组成的“团队科学”项目，在COVID之前，有13名访问学者和赠款 发展奖。这些举措有助于在调查人员之间建立合作精神，并导致 由洛杉矶CATS试点项目获奖者撰写的253篇同行评审稿，117份演示文稿和78份赠款 在本供资周期的头四年，总额为6960万美元。此外，11名试点项目获奖者 在自己的母校获得学术晋升。在下一个五年周期中，我们将在这些成功的基础上再接再厉 并扩大得到支持的初级调查人员的数量，在这些调查人员中，我们将优先考虑代表性不足的少数民族 调查人员，并确定可以迅速竞争的、竞争激烈的机构间项目 用于重大的联邦拨款计划。我们还将继续通过优先考虑早期阶段来展望未来 研究人员和临床医生可以将新的概念和研究技术引入到 南湾。为实现这些目标，我们将落实三个具体目标。首先，我们将征集、审查和 建议为洛杉矶CATS试点项目赠款提供资金，预计这些奖项将导致高质量的临床和 翻译研究申请校外资助。我们将优先考虑早期调查人员和初级调查人员 来自代表不足的少数族裔群体的教师。第二，建设跨机构侦查队伍。 准备迅速竞争解决现有和新出现疾病的主要联邦拨款倡议 这影响了我们的人口，并加剧了南部海湾地区的健康差距。第三，我们将提供机会 对于早期研究人员和临床医生来说，从事新的研究培训机会和学习新奇， 采用尖端方法进行、转化和实施创新研究，包括临床试验。在 在下一个5年周期结束时，我们预计将增加资助的年轻研究人员的数量， 包括代表不足的少数族裔研究人员，他们可以支持大型多机构研究项目 和英才中心，并确保我们能够解决我们区域的卫生保健需求和健康差距 使用尖端科学方法。

Project Summary: Pilot Projects Program Core The goal of the Pilot Projects Program (PPP) Core is to increase the number of junior investigators trained in clinical and translational research that work with well-established teams of senior scientists developing innovative research programs to address the chronic disease burden in Louisiana. This is of particular significance to our region given the major health disparities. To achieve this goal, the PPP Core provides direct and significant financial support for pilot projects, enables these projects to utilize the expertise and resources of other cores, facilitates in-kind support across collaborating institutions, and fosters education and training that enhances each awardee's long-term success as an independent translational investigator. While the current funding cycle was challenging because of COVID, the PPP funded 36 pilot projects across institutions, including 3 multi- institutional, multi-investigator “team science” projects, and prior to COVID, 13 Visiting Scholar and Grant Development awards. These initiatives helped build a collaborative spirit among investigators and resulted in 253 peer reviewed manuscripts by LA CaTS Pilot Project awardees, 117 presentations, and 78 grants awarded totaling $69.6 million in the first four years of the current funding cycle. Further, 11 pilot project awardees were academically promoted at their home institution. During the next 5-year cycle we will build on these successes and expand the number of supported junior investigators where we will prioritize underrepresented minority investigators and identify “shovel-ready” highly competitive interinstitutional programs that can rapidly compete for major federal grant initiatives. We will also continue to look towards the future by prioritizing early-stage investigators and clinicians who can import novel concepts and research techniques to research centers in the Gulf South. To achieve these goals, we will implement three specific aims. In the first we will solicit, review, and recommend funding for LA CaTS Pilot Project grant awards that are expected to lead to high quality clinical and translational research applications for extramural funding. We will prioritize early-stage investigators and junior faculty from underrepresented minority populations. Second, we will build inter-institutional teams of investigators that are poised to rapidly compete for major federal grant initiatives addressing existing and emerging diseases affecting our population and worsening health disparities in the Gulf South. Third, we will provide opportunities for early-stage investigators and clinicians to engage in new research training opportunities and learn novel, cutting edge methods to conduct, translate and implement innovative research including clinical trials. At the conclusion of the next 5-year cycle we expect to have increased the number of funded young investigators, including underrepresented minority investigators who can support large multi-institutional research programs and centers of excellence and ensure that we can address health care needs and health disparities in our region using cutting edge scientific approaches.