MIND Institute Intellectual and Developmental Disabilities Research Center

项目总结--总体 本申请寻求资金，以继续智力与发展研究所 加州大学戴维斯分校残疾研究中心(IDDRC)。IDDRC成立于2013年 是该网络14个国际数据中心中最新的一个。思维研究所国际发展研究中心将解决四个具体目标。 目标1是进行跨学科的翻译研究，以深入了解疾病的性质、原因和 预防和治疗缺碘的后果，并导致采用创新的循证预防和治疗方法。对这件事 最后，我们提出了81个外部资助的项目，这些项目反映了集成生物行为的主题 IDD的特征，遗传和环境对IDD的贡献，以及IDD的治疗。这些项目 由来自16个学术部门和5所学校/学院的43名调查人员领导。68个项目由 NIH，包括NICHD的16个。目标2是通过以下方式加快跨学科翻译研究的步伐 运营具有成本效益、创新和广泛使用的科学核心。除了管理核心，我们还 提出四个科学核心。临床翻译核心将促进招募不同的样本 人类参与者，提供专门的临床专业知识来诊断和表征参与者，支持 复杂的表型，收集和储存生物标本，并将数字技术整合到治疗研究中。 生物和分子分析核心将提供以下领域的专门知识和技术 免疫功能、细胞和分子成像、表观遗传学和环境暴露 神经发育。啮齿动物行为核心将提供小鼠和大鼠行为的分析，指导 开发突变的啮齿动物模型，并支持药物安全性和有效性的临床前评估。这个 生物统计学、生物信息学和研究设计核心将为研究设计、创建 电子数据捕获和管理系统，以及复杂多维数据集的统计分析。 目标3是改善IDD患者的生活，并通过发展 一个传播和实施科学发现的强有力的计划。该计划将涉及多条途径 与目标专业人员和政策制定者进行沟通，接触不同的社区，同时获得 碘缺乏病患者及其家人的观点。目标4是进行一个标志性的研究项目， 在母体自身抗体中检查结局的异质性和这些结局背后的机制 相关(MAR)自闭症谱系障碍(ASD)，可能占ASD病例的20%。这个 该项目将利用现有的人类临床数据，为建立大鼠模型系统提供信息，以进行测试 关于因果机制的假设。标志性项目涉及三个RFA主题：预防和 减轻可能导致缺碘的暴露、干预措施或生物标记物的影响 在一种以上的缺碘状态下的治疗、生物标记物的开发或评估措施。

PROJECT SUMMARY – OVERALL The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The MIND Institute IDDRC will address four specific aims. Aim 1 is to conduct interdisciplinary translational research that yields insights into the nature, causes, and consequences of IDD and leads to innovative evidence-based approaches to prevention and treatment. To this end, we propose 81 externally funded projects that reflect the themes of Integrated Biobehavioral Characterization of IDD, Genetic and Environmental Contributions to IDD, and Treatment of IDD. These projects are led by 43 investigators from 16 academic departments and 5 schools/colleges. 68 projects are funded by the NIH, including 16 by NICHD. Aim 2 is to accelerate the pace of interdisciplinary translational research via the operation of cost-effective, innovative, and widely used scientific cores. In addition to an Administrative Core, we propose four scientific cores. The Clinical Translational Core will facilitate recruitment of diverse samples of human participants, provide specialized clinical expertise to diagnose and characterize participants, support complex phenotyping, collect and store biospecimens, and integrate digital technologies into treatment studies. The Biological and Molecular Analysis Core will provide access to expertise and technologies in the areas of immune function, cellular and molecular imaging, epigenetics, and environmental exposures as they relate to neural development. The Rodent Behavior Core will provide assays of mouse and rat behavior, guidance in the development of mutant rodent models, and support for preclinical evaluations of drug safety and efficacy. The Biostatistics, Bioinformatics, and Research Design Core will provide support for study design, creation of electronic data capture and management systems, and statistical analysis of complex multidimensional datasets. Aim 3 is to improve the lives of people with IDD and reduce health and social disparities in care by developing a robust plan for disseminating and implementing scientific discoveries. The plan will involve multiple paths of communication to target professionals and policy makers, reach diverse communities, while being informed by the perspectives of people with IDD and their families. Aim 4 is to conduct a signature research project that examines the heterogeneity of outcomes and mechanisms underlying those outcomes in maternal autoantibody related (MAR) autism spectrum disorder (ASD), which may account for as much as 20% of ASD cases. The project will make use of existing human clinical data to inform the creation of rat model systems to test hypotheses about causal mechanisms. The signature project addresses three RFA themes: Preventing and mitigating the impact of exposures that can cause IDD, Outcome measures or biomarkers for interventions or treatments, and Development of biomarkers or assessment measures in more than one IDD condition.