Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)
Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)
批准号:
10818803
负责人:
PETER Karl SORGER
金额:
$75.74万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
已结题
起止时间:
2023-04-04 至 2024-08-31
关键词:
3-DimensionalAtlasesCellsClinicalClinical DataCommunicationComplexComputer softwareCutaneousDataData AnalysesData ElementDiagnosisDiseaseEnsureGeneticGoalsHematologyHistopathologyHumanImageMalignant NeoplasmsMetadataMethodsMolecularParticipantPatientsProcessPublicationsSamplingTissue MicroarrayVisualization softwareWorkdata disseminationdata portaldata sharingdata submissionfollow-upimprovedmelanomamembermultiplexed imagingopen datapremalignantpreventprocess optimizationprogression riskquality assuranceskin lesionsoftware developmentthree-dimensional visualizationtooltranscriptomics
中文摘要
摘要
皮肤和血液起源癌前病变中心(PATCH)的总体目标是
中心)将在补充年度重点关注数据分析和传播。政府当局
和项目管理团队将专注于中心的科学管理,与
NCI员工和HTAN中心,并确保定期的数据存储。他们将指导其他中心
委员会成员应集中精力开展与完成和传播中心地图集有关的所有活动。我们
预计生物标本和临床团队将专注于管理临床和生物标本元数据,
参与对结果的解释,以供出版和其他传播活动。最
图谱和SARDANA TNP的表征活动将在
补充,但将进行额外表征,以保证质量并进行随访
在出版过程中进行实验。大部分活动将在数据分析,软件,
开发和传播复杂的图像数据。该中心将致力于3D分割
和可视化工具,MCMICRO管道的改进,以及Minerva Story的改进
工具,以适应3D可视化以及临床和生物标本元数据。我中心将
继续与DCC合作,开发和优化共享高度复杂成像的流程
数据
英文摘要
ABSTRACT
The overall aims of the Center for Pre-cancer Atlases of Cutaneous and Hematologic Origin (PATCH
Center) will pivot in the supplemental year to focus on data analysis and dissemination. The Administration
and Project Management team will focus on the scientific management of the Center, communicate with
NCI staff and HTAN Centers, and ensure regular data deposition. They will guide the other Center
members to focus on all activities related to the completion and dissemination of the Center atlas. We
anticipate the biospecimen and clinical teams will focus on curating clinical and biospecimen metadata and
participating in the interpretation of results for publication and other dissemination activities. Most
characterization activities for the atlas and the SARDANA TNP will be completed prior to the initiation of
the supplement, but additional characterization will be performed for quality assurance and follow up
experimentation during the publication process. The bulk of the activities will be in data analysis, software
development, and dissemination of complex image data. The Center will be working on 3D segmentation
and visualization tools, improvements to the MCMICRO pipeline, and advancements to Minerva Story
tools to accommodate 3D visualization as well as clinical and biospecimen metadata. Our Center will
continue to work with the DCC to develop and optimize the process for sharing highly complex imaging
data.
期刊论文(5)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1093/bioinformatics/btac544
发表时间:
2022-09-30
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1126/sciadv.adg4128
发表时间:
2023-06-23
期刊:
SCIENCE ADVANCES
影响因子:
13.6
作者:
[Lecky, Emmalyn, Mukherji, Atreyi, German, Rebecca, Antonellis, Gabriella, Lin, Jia-Ren, Yorsz, Michael, McQueeney, Kelley E., Ryan, Jeremy, Ng, Kimmie, Sicinska, Ewa, Sorger, Peter K., Letai, Anthony, Bhola, Patrick D.]
通讯作者:
Bhola, Patrick D.
Administrative Core
-
批准号:10900843
-
项目类别:
-
资助金额:$50.3万
-
财政年份:2023
-
负责人:PETER Karl SORGER
-
依托单位:
Administrative Core
-
批准号:10494414
-
项目类别:
-
资助金额:$25.35万
-
财政年份:2021
-
负责人:PETER Karl SORGER
-
依托单位:
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
-
批准号:10405812
-
项目类别:
-
资助金额:$25.35万
-
财政年份:2021
-
负责人:PETER Karl SORGER
-
依托单位:
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
-
批准号:10343835
-
项目类别:
-
资助金额:$192.57万
-
财政年份:2018
-
负责人:PETER Karl SORGER
-
依托单位:
Project 1: Multi-scale modeling of adaptive drug resistance in BRAF-mutant melanoma
-
批准号:10343839
-
项目类别:
-
资助金额:$53.52万
-
财政年份:2018
-
负责人:PETER Karl SORGER
-
依托单位:
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
-
批准号:9886211
-
项目类别:
-
资助金额:$214.92万
-
财政年份:2018
-
负责人:PETER Karl SORGER
-
依托单位:
Admin-Core-001
-
批准号:10025683
-
项目类别:
-
资助金额:$21.19万
-
财政年份:2018
-
负责人:PETER Karl SORGER
-
依托单位:
Administrative Core
-
批准号:10343836
-
项目类别:
-
资助金额:$24.56万
-
财政年份:2018
-
负责人:PETER Karl SORGER
-
依托单位:
The HMS Laboratory of Systems Pharmacology
-
批准号:8769531
-
项目类别:
-
资助金额:$234.61万
-
财政年份:2014
-
负责人:PETER Karl SORGER
-
依托单位:
Pharmaco Response Signatures and Disease Mechanism
-
批准号:8926239
-
项目类别:
-
资助金额:$214.55万
-
财政年份:2014
-
负责人:PETER Karl SORGER
-
依托单位:
Pharmaco Response Signatures and Disease Mechanism
-
批准号:9316354
-
项目类别:
-
资助金额:$214.52万
-
财政年份:2014
-
负责人:PETER Karl SORGER
-
依托单位:
Pharmaco Response Signatures and Disease Mechanism
-
批准号:8787853
-
项目类别:
-
资助金额:$214.55万
-
财政年份:2014
-
负责人:PETER Karl SORGER
-
依托单位:
The HMS Laboratory of Systems Pharmacology
-
批准号:9278199
-
项目类别:
-
资助金额:$214.96万
-
财政年份:2014
-
负责人:PETER Karl SORGER
-
依托单位:
Pharmaco Response Signatures and Disease Mechanism
-
批准号:9754857
-
项目类别:
-
资助金额:$214.52万
-
财政年份:2014
-
负责人:PETER Karl SORGER
-
依托单位:
The HMS Laboratory of Systems Pharmacology
-
批准号:8904035
-
项目类别:
-
资助金额:$199.42万
-
财政年份:2014
-
负责人:PETER Karl SORGER
-
依托单位:
Pharmaco Response Signatures and Disease Mechanism
-
批准号:9098801
-
项目类别:
-
资助金额:$214.52万
-
财政年份:2014
-
负责人:PETER Karl SORGER
-
依托单位:
BUILDING CELL TYPE-SPECIFIC SIGNALING MODELS IN BREAST CANCER CELL LINES
-
批准号:8365480
-
项目类别:
-
资助金额:$2.87万
-
财政年份:2011
-
负责人:PETER Karl SORGER
-
依托单位:
High Performance Clustered Storage for Image Management
-
批准号:7792114
-
项目类别:
-
资助金额:$49.46万
-
财政年份:2010
-
负责人:PETER Karl SORGER
-
依托单位:
Quantitative Analysis of Cell Death Pathways in Cancer
-
批准号:7785672
-
项目类别:
-
资助金额:$29.0万
-
财政年份:2009
-
负责人:PETER Karl SORGER
-
依托单位:
Systems Biology of cell Decision Processes
-
批准号:7930733
-
项目类别:
-
资助金额:$22.85万
-
财政年份:2009
-
负责人:PETER Karl SORGER
-
依托单位:
海外基金