Academic-Industrial Partnership for Translation of Acoustic Angiography

项目总结 传统的灰阶超声成像因其可获得性、低成本、 可携带性和安全性。超声波是唯一一种变得更小、更便宜的手段，因此 更容易为农村和服务不足的人口提供服务。现代超声系统现在可以手持和 成本约为核磁共振系统的千分之一。然而，主要的挑战仍然是超声波对疾病的特异性很差。 实体癌症。提高超声对实体肿瘤的特异性和敏感性的技术将具有 在及早发现和减少不必要的活检、挽救生命和减少医疗保健方面产生重大影响 成本。我们的团队正在开发一种创新的微血管成像技术，基于硬件方面的进展 多频超声换能器，以及专门检测对比度的信号处理技术 代理，同时减少背景噪音。使用第一代这种技术的初步数据表明 提高我们区分癌症病变和健康组织的能力的巨大潜力，基于 解决健康组织中血管新生血管形态差异的能力。这份多元化副刊 将支持Jadyn Cook女士在超声生物医学工程方面的职业发展和科学培训 改善我们对癌症的检测的工具。她与家长拨款相关的研究重点将集中在 双频超声技术的开发和测试。

PROJECT SUMMARY Traditional grayscale ultrasound imaging is widely used in diagnostics because of its accessibility, low-cost, portability, and safety. Ultrasound is the only modality which is getting smaller and less expensive, and thereby more accessible to rural and underserved populations. Modern ultrasound systems can now be handheld and cost ~ 1/1000th of an MRI system. However, the major challenge remains that ultrasound is poorly specific to solid cancers. Techniques to improve the specificity and sensitivity of ultrasound to solid tumors would have a significant impact in early detection and reduction of unnecessary biopsies, saving lives and reducing healthcare costs. Our team is developing an innovative microvascular imaging technology, based on hardware advances in multi-frequency ultrasound transducers, as well as signal processing techniques to specifically detect contrast agents while reducing background noise. Preliminary data using the first generation of this technology has shown substantial potential to improve our ability to differentiate cancerous lesions from healthy tissue, based on the ability to resolve differences in angiogenic vasculature morphology from healthy tissue. This diversity supplement will support Ms. Jadyn Cook’s career development and scientific training in biomedical engineering of ultrasound tools to improve our detection of cancer. Her research focus relevant to the parent grant will focus on the development and testing of dual-frequency ultrasound techniques.