Maternal acetaminophen use and childhood cancer

项目摘要/摘要 本提案是对NOT-OD-22-137的回应：提供行政补充，包括 (了解唐氏综合症的终生共生状况调查)项目。我们的目标是 处理组成部分2：“将一大批唐氏综合症患者聚集在一起， 进行深入的表型鉴定并研究共存条件。我们将在230万人的大型研究基础上再接再厉 在台湾出生，我们正在调查怀孕期间母亲的药物摄入量及其相关性 患有儿童癌症；家长研究的目标不会改变。在美国，唐氏综合症的人口流行率 美国每年有25万人患有综合症(DS)，6000名患有DS的儿童出生。唐氏症儿童 综合症会显著增加患白血病的风险，并增加患其他一些疾病的风险。 这项拟议的研究将利用来自一大批台湾儿童的数据来检查共病情况 在唐氏综合症儿童中。本研究的对象包括2004-2015年间在台湾出生的所有儿童。降下来 症状和其他诊断将从台湾的国家健康保险数据库中确定。 结果将在一大批丹麦儿童中得到证实。这个项目的目标是更好地理解 唐氏综合征患者的合并症，以改进筛查指南和患者护理管理。

Project Summary/Abstract This proposal is responsive to NOT-OD-22-137: Availability of Administrative Supplements for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project. We aim to address Component 2: “Assembly of a large cohort of individuals with Down syndrome across the lifespan to perform deep phenotyping and study co-existing conditions.” We will build upon our large study of 2.3 million Taiwanese births, in which we are investigating maternal pharmaceutical intake in pregnancy and associations with childhood cancer; Aims of the parent study will not change. In the US, the population prevalence of Down syndrome (DS) is 250,000 persons, and 6000 children with DS are born in the US each year. Children with Down syndrome have a substantially increased risk for leukemia, and elevated risk for a number of other conditions. The proposed study will utilize data from a large cohort of Taiwanese children to examine comorbid conditions in children with Down syndrome. Participants in our study include all children born in Taiwan 2004-2015. Down syndrome and other diagnoses will be ascertained from the National Health Insurance Database in Taiwan. Results will be confirmed in a large cohort of Danish children. The goals of this project are to better understand comorbidities in Down syndrome to improve screening guidelines and management of patient care.