Cognitive Neuroscience of Development and Aging (CONDA) Center

项目摘要 家长奖的目标（原始摘要文本） 这一生物医学研究卓越中心（COBRE）的申请将启动一个正式的中心， 支持和扩大内布拉斯加州的神经成像和临床认知神经科学研究，重点是 寿命的发展。对于奥马哈社区的人类神经科学研究来说，这是一个合适的时机， 在区域和世界各地，许多新的研究工具和政府倡议旨在阐明 生物医学的下一个前沿发展与衰老的认知神经科学（Cognitive Neuroscience of Development and Aging，CONDA） 中心将为来自内布拉斯加大学等四所院校的教师提供关键资源和支持 医学中心（UNMC），男孩镇国家研究医院，内布拉斯加大学奥马哈分校， 克雷顿大学。该中心的行政核心将设在联合国军事委员会， 距离其他机构各两英里，将由培训，评估，参与， 管理和指导领域（即，TEEAM核心）。新的康达中心还将包括一个国家- 最先进的神经成像采集和分析核心，以及对四个主要COBRE的广泛支持 由NIH定义的早期研究人员组成的一个有前途的小组领导的研究项目。中心成立后， TEEAM核心将立即实施一系列旨在开发人类的新计划， 认知神经科学在康达校园和整个地区。TEEAM核心也将迅速 实施全面的研究支持结构，包括神经影像核心设施，培训 机会，试点项目和小额赠款计划，新的研讨会系列，博士后奖学金，实习生， 增加临时和长期实验室工作人员的船舶，以及参与者登记册，以加强招聘。 与此同时，TEEAM核心将促进COBRE主要研究项目的成功启动， 通过辅导网络办法，实施职业发展和评价支助系统， 监控进度，确保初级PI及其指导团队达到关键里程碑。按照新的 神经影像采集和分析核心设施将是唯一致力于研究的核心， 人类大脑研究在内布拉斯加州，并将提供最先进的工具，区域科学家 用于神经成像和神经调节，包括研究专用MRI和MEG系统。新中心 还将获得特殊的机构支持，包括对CONDA计划的财政支持， 设备费用和核心人员。整个CONDA团队包括一组既定的神经系统专业研究员， 成像，脑动力学，衰老，大脑和认知发展，以及一个强大的新兴队列， 初级研究人员使用创新的认知和情感神经科学方法来解决主要问题 在人类神经科学中的应用。 团队科学补充提案的目标 我们的团队科学补充提案响应了NOT-GM-23-034 [特别关注通知（NOSI）： 为团队科学发展项目提供IDEA奖励的行政补充]，以及 它提出了针对CoNDA中心使命核心主题的研究，研究认知 发育和衰老的神经科学。具体来说，我们的提案的标题是“阐明多基因 AD风险对大脑，认知，社会情绪和行为结果的发展和老龄化，使用一种新的 多模式方法和多代样本”。拟议项目的核心前提是， 遗传性AD风险因素对寿命发育的影响可以通过提高速度，严格性， 和有效性，丰富的儿童样本与匹配，多代的家庭老人的样本。 在此前提下，我们建议研究阿尔茨海默病多基因风险（AD-PRS）对 发展和老龄化采用创新的多代办法。我们的新研究将补充和 扩展NIA资助的内布拉斯加州儿童阿尔茨海默病多基因风险研究（“PRANK”，R 01 AG 064247）已招募了180多名儿童参与者。在此，我们将入组新样本（N=72） 由PRANK登记者的家庭长者（年龄65-85岁）组成。我们将测量大脑，认知， 来自老年人的神经精神变量，沿着AD风险因素（遗传）和AD生物标志物 （神经病理学）。这种方法将使我们能够追求我们的四个具体目标：目标1）衡量广告相关 Warren博士领导的PRANK参与者的家族长辈中的神经病理学和其他大脑变量）;目的2） 评估AD相关认知/神经精神状态与家族性老年人生物学年龄之间的关系 由CPL Beadle博士领导的PRANK参与者;目标3）测量社会因素，包括社会网络规模， 由CPL陈博士领导的PRANK参与者的家庭长者的关系质量和二元互动;以及 目的4）测量遗传性AD危险因素和家庭连通性对多模态脑的交互作用 年龄差距使用机器学习由CPL王领导。我们的创新方法将提供以下方面的关键发现 AD-PRS对发育和衰老的影响，否则需要数十年的纵向监测 同样的参与者。至关重要的是，我们的团队科学方法是这个项目的重要组成部分。我们的团队 包括认知神经科学，阿尔茨海默病，发育，衰老，多种 神经影像学方法、遗传学、计算神经科学、神经病理学、生物样本分析等。 只有结合我们优秀团队成员的努力，我们才能追求如此规模的项目，并且 我们通过完成这个项目建立的团队将使我们能够在不久的将来获得更多的研究资金。

Project Summary Goals of Parent Award (Original Abstract Text) This application for a Center of Biomedical Research Excellence (COBRE) would initiate a formal Center to lead, support, and expand neuroimaging and clinical cognitive neuroscience research in Nebraska, with an emphasis on lifespan development. It is an opportune moment for human neuroscience research in the Omaha community, regionally, and across the world, with many new research tools and government initiatives intended to illuminate the next frontier of biomedicine. The proposed Cognitive Neuroscience of Development and Aging (CONDA) Center will provide critical resources and support to faculty from four institutions: the University of Nebraska Medical Center (UNMC), the Boys Town National Research Hospital, the University of Nebraska – Omaha, and Creighton University. The Administrative Core of the CONDA Center will be housed at UNMC, which is less than two miles from each of the other institutions, and will be comprised of Training, Evaluation, Engagement, Administration, and Mentoring areas (i.e., the TEEAM Core). The new CONDA Center will also include a state- of-the-art Neuroimaging Acquisition and Analysis Core, as well as extensive support for four primary COBRE research projects led by a promising group of NIH-defined early-stage investigators. Upon initiation of the Center, the TEEAM Core would immediately implement a series of new programs that are designed to develop human cognitive neuroscience on the CONDA Campus and across the region. The TEEAM Core would also rapidly implement a comprehensive research support structure that includes the Neuroimaging Core facility, training opportunities, pilot projects and mini-grants programs, a new seminar series, postdoctoral fellowships, intern- ships for growing temporary and long-term laboratory staffing, and a participant registry to enhance recruitment. In parallel, the TEEAM Core would promote the successful launch of the primary COBRE research projects and, through a mentoring network approach, implement a career development and evaluation support system to monitor progress and ensure Junior PIs and their mentoring teams reach critical milestones. As per the new research core, the Neuroimaging Acquisition and Analysis Core facility would be the only core dedicated to human brain research in the state of Nebraska, and would provide regional scientists with state-of-the-art tools for neuroimaging and neuromodulation, including research-dedicated MRI and MEG systems. The new Center would also receive exceptional institutional support, including financial support for CONDA programs, major equipment expenses, and Core staffing. The overall CONDA team includes an established group of PIs in neuro- imaging, brain dynamics, aging, and brain and cognitive development, as well as a strong cohort of emerging junior investigators using innovative cognitive and affective neuroscience methods to address major questions in human neuroscience across the lifespan. Goals of the Team Science Supplement Proposal Our team science supplement proposal responds to NOT-GM-23-034 [Notice of Special Interest (NOSI): Availability of Administrative Supplements to IDeA Awards to Fund Team Science Development Projects], and it proposes research targeting a topic at the core of the CoNDA Center’s mission, studying the cognitive neuroscience of development and aging. Specifically, our proposal is titled “Elucidating the effects of polygenic AD risk on brain, cognitive, socioemotional, and behavioral outcomes in development and aging using a novel multimodal approach and a multigenerational sample”. The central premise of the proposed project is that lifespan development effects of genetic AD risk factors can be assessed with increased speed, rigor, and validity by enriching child samples with a matched, multigenerational sample of familial elders. Building on this premise, we propose to study the effects of Alzheimer’s disease polygenic risk (AD-PRS) on development and aging using an innovative multigenerational approach. Our new study will complement and extend the NIA-funded Polygenic Risk of Alzheimer’s disease in Nebraska Kids study (“PRANK”, R01 AG064247) that has enrolled more than 180 child participants. Here, we will enroll a new sample (N=72) consisting of the familial elders (age 65-85 years) of PRANK enrollees. We will measure brain, cognitive, and neuropsychiatric variables from the older adults along with AD risk factors (genetic) and AD biomarkers (neuropathological). This approach will allow us to pursue our four specific aims: Aim 1) Measure AD-related neuropathology and other brain variables in familial elders of PRANK participants led by Dr. Warren); Aim 2) Evaluate associations between AD-related cognitive/neuropsychiatric status and biological age in familial elders of PRANK participants led by CPL Dr. Beadle; Aim 3) Measure social factors including social network size, relationship quality, and dyadic interactions in familial elders of PRANK participants led by CPL Dr. Chen; and Aim 4) Measure the interactive effect of genetic AD risk factors and family connectedness on multi-modal brain age gaps using machine learning led by CPL Wang. Our innovative approach will provide key findings regarding the effects of AD-PRS in development and aging that would otherwise require decades of longitudinal monitoring of the same participants. Crucially, our team science approach is an essential part of this project. Our team includes diverse expertise in cognitive neuroscience, Alzheimer’s disease, development, aging, multiple neuroimaging methods, genetics, computational neuroscience, neuropathology, biospecimen assays, and more. Only by combining the effort of our outstanding team members could we pursue a project of this scope, and the team we build by completing this project will allow us to pursue additional research funding in the near future.