AFFORDABLE MULTICHANNEL DATA ACQUISITION SYSTEM

该提案解决了NIMH确定的创新需求， 计算机接口可以连续采集、分析和存储 用于研究和临床的神经生理学数据。我们将开发 经济实惠的数据采集硬件和软件， 多通道神经反应的并行记录、显示和分析 基于Pentium的PC系统。重点是与以下系统一起使用的系统 用于急性和慢性动物的多达100个皮质内电极的阵列 调查事务所 硬件系统将： i）放大100个神经数据通道， ii）获取并存储超阈值动作电位的次数 波形或单元标识符（第二阶段）。 软件工具将： i）控制数据采集过程， ii）显示多单位尖峰活性，和 iii）显示3-D神经活动（两个空间维度和一个时间维度）。 数据文件结构将适合导入第三方数据 分析软件系统将通过综合数据进行验证， 视觉刺激网络表征的生理学研究 以及药物对自发活动和连通性的影响 神经元的数量。 拟定商业应用： 经济实惠的数据采集系统将使神经科学 研究人员将多电极阵列用于"切片"工作， 植入灵长类动物、猫科动物和啮齿类动物模型的神经系统 来研究并行处理和与之相关的连通性， 正常或异常的精神功能。该系统还可用于开发 治疗药物;并研究两者的潜在机制， 滥用药物对神经系统的影响， 失忆

This proposal addresses the need identified by the NIMH for innovative computer interfaces that can continuously acquire, analyze and store neurophysiological data for research and clinical use. We will develop affordable data acquisition hardware and software that will permit parallel recording, display, and analysis of multichannel neural responses with a Pentium-based PC system. The focus is on systems for use with arrays of up to 100 intracortical electrodes for acute and chronic animal investigations. The hardware systems will: i) amplify 100 channels of neural data, ii) acquire and store the times of super-threshold action potential waveforms or the unit identifiers(Phase II). The software tools will: i) control data acquisition processes, ii) display multi-unit spike activity, and iii) display 3-D neural activity (two spatial and one time dimension). Data file structure will be suitable for importing into third party data analysis software. Systems will be validated with synthesized data and in physiological investigations of network representations of visual stimuli in feline Vl, and drug effects on spontaneous activity and connectivities of neurons in feline sensory cortex. PROPOSED COMMERCIAL APPLICATION: The affordable data acquisition system will enable neuroscience researchers to use multielectrode arrays in 'slice' work and chronically implanted in the nervous systems of primates, felines, and rodent models to investigate the parallel processing and connectivities associated with normal or aberrant mental function. The system can also be used to develop therapeutic drugs; and to study the underlying mechanism both of the effect of drugs of abuse on the nervous system, and of the acquisition and loss of memory.