THREE-DIMENSIONAL TOMOGRAPHIC ANGIOGRAPHY

识别将从特定治疗中获益的患者 手术需要准确评估狭窄的严重程度， 它们的几何形状和空间方向。 大多数治疗决定都是 目前基于通过数字减影获得的信息 动脉造影 标准血管造影图像不提供 血管造影师有足够的信息需要作出治疗 决策 这个为期五年的项目的长期目标是开发一个 三维（3-D）断层扫描（称为体积断层扫描）数字 血管造影成像技术，为血管造影师提供有用的3D 诊断和治疗决策所需的血管图像。 容积层析数字血管造影（VTDA）结合容积层析成像 成像原理与数字血管造影的成像原理相同。 VTDA只需要 单次造影剂注射和容积扫描， 描述头颈部血管解剖结构和狭窄。 这种VDTA技术将具有强大的临床影响，因为它将 简化手术，减少造影剂剂量、总X线剂量 和手术时间，同时为血管造影师提供直接， 准确测量狭窄的严重程度， 几何形状和空间方位。 VTDA将通过计算机模拟进行开发和验证， 体模和在旋转体积断层扫描上进行的动物研究 使用耦合到电荷耦合器件的图像增强器的成像器 (CCD)作为探测器。 具体而言，拟议研究的目的是： 1)通过计算机进行VTDA优化研究 模拟; 2）实施优化的造影剂注射方案 并制定采集协议和血管重建 算法; 3）产生原型旋转体积层析成像 通过将可用的CT扫描仪的线性探测器替换为 2-D探测器; 4）进行体模研究并优化系统 性能;以及5）将原型成像器用于动物实验， 人类研究的前奏

Identification of patients who will benefit from specific therapeutic procedure requires the accurate assessment of the severity of stenoses, their geometry and spatial orientation. Most therapeutic decisions are currently based on information obtained through digital subtraction angiography. Standard angiographic images are not providing angiographers with sufficient information needed to make therapeutic decisions. The long-term goal of this five year project is to develop a three-dimensional (3-D) tomographic (called volume tomographic) digital angiography imaging technique to provide angiographers with useful 3-D vascular images needed for diagnostic and therapeutic decisions. Volume tomographic digital angiography (VTDA) combines volume tomographic imaging principles with those of digital angiography. VTDA requires only a single contrast injection and volume scan to provide a true 3-D description of vascular anatomy and stenoses in head and neck. This VDTA technique will have a strong clinical impact since it will simplify the procedure, and reduce contrast media dose, total x-ray dose and the procedure time, while supplying the angiographer with direct, umbiguous and accurate measurement of the severity of the stenoses, their geometry, and spatial orientation. VTDA will be developed and validated through computer simulation, phantom, and animal studies performed on a rotational volume tomographic imager that uses an image intensifier coupled to a charge-coupled device (CCD) as a detector. Specifically, the aim of the proposed research are: 1) to perform studies on optimization of VTDA through computer simulation; 2) to implement optimized contrast agent injection protocols and to develop acquisition protocols and vascular reconstruction algorithms; 3) to produce a prototype rotational volume tomographic imager by replacing the linear detector of an available CT scanner with a 2-D detector; 4) to perform phantom studies and optimize the system performance; and 5) to use the prototype imager for animal experiments as a prelude to human studies.