PLASMA D CHIRO INOSITOL LEVELS PREDICT CIRCULATING TRIGLYCERIDES IN DIABETICS

对罕见的肌醇异构体D-手性肌醇的兴趣一直是 它在肌醇磷酸聚糖分子中的发现点燃了它， 模拟胰岛素的某些肌动蛋白，包括对脂质的体外作用 新陈代谢. 为了确定D-手性肌醇是否可能 在糖尿病患者的临床脂质代谢中， 通过负离子气体测量的D-手性肌醇的血浆水平 色谱/质谱分析，并将其与循环 脂蛋白和其他协变量的横断面研究73 糖尿病患者和42名正常人。 在一个28人的小组中， 胰岛素缺乏型NIDDM受试者的糖化血红蛋白大于 10%时，血浆D-手性肌醇水平呈显著正相关， 与血浆甘油三酯相关， 观察到血浆甘油三酯的预测因子。 没有任何关系 血浆L-手性肌醇与血浆甘油三酯的比值。 血浆 在非糖尿病患者中，D-手性肌醇与血脂无关。 血浆D-手性肌醇与糖尿病的密切关系 糖尿病受试者的血浆甘油三酯水平表明， D-手性肌醇代谢紊乱可能是糖尿病的一个组成部分 血脂异常

Interest in the rare inositol isomer D-chiro-inositol has been kindled by its discovery in inositol phosphoglycan molecules which mimic certain actins of insulin including in vitro effects on lipid metabolism. In order to determine whether D-chiro-inositol might be important in clinical lipid metabolism in diabetic patients, we measured plasma levels of D-chiro-inositol by negative ion gas chromatography/mass spectrometry and compared them to circulating lipoproteins and other covariates in a cross-sectional study of 73 diabetics and 42 normal subjects. In a subgroup of 28 relatively insulin-deficient NIDDM subjects with glycohemoglobin greater than 10%, plasma D-chiro-inositol level was positively and linearly correlated with plasma triglycerides and was the strongest independent predictor of plasma triglycerides observed. There was no relation of plasma L-chiro-inositol to plasma triglycerides. Plasma D-chiro-inositol was not related to lipids in nondiabetic s ubjects. Theclose statistical association between plasma D-chiro-inositol and plasma triglyceride levels in diabetic subjects suggests that disordered D-chiro-inositol metabolism may be a component of diabetic dyslipidemia.