WF DISC: Navigating Data Solutions for Chronic Pain and Opioid Use Disorder

项目摘要 预防阿片类药物过量的多层面挑战需要比单一网络更大的解决方案 项目虽然HHS和NIH正专注于从多个角度制定预防策略， 混合这些数据将需要复杂的数据解决方案，以超越孤立。虽然我们还不知道 将阿片类药物过量数据的要素结合在一起将是最有效的，以 允许FAIR（可查找、可解释、可互操作、可重用）格式构建以实现该潜力。目标 的治疗D2A计划是发展阿片类药物过量监测在真实的时间，但这将需要显着 结合临床和信息学知识，使这个系统在一起。为了实现这一目标，我们的 该提案是对RFA-DA-22 - 052的响应，旨在为HEAL设计灵活和创造性的信息解决方案 Data2Action（HD2A）网络。WF数据基础设施支持中心（DISC）是一个高质量的 临床信息学团队将提供直接支持、指导和帮助，以确保数据 在最短的时间内为HEAL D2A创新生产最高质量的基础设施 项目作为U24数据中心，我们的总体目标是识别和消除数据基础架构障碍 （知识和技术），使HD2A项目的成功完成。本提案的目的 是应对HD2A网络的预期和意外数据挑战，包括 创新项目，以确定工具，提供数据支持，并提供培训援助。要全面完成 通过顺利完成这些分阶段的目标来实现这一目标。为了支持整体假设， HEAL D2A网络，在目标1中，WF DISC的研究启动核心将确定和开发数据基础设施 支持和工具。在目标2中，WF DISC的研究指导核心将与HD2A RASC和MERC合作 提供数据测量、分析和可视化支持和协调。在Aim 3中，WF DISC的 研究传播中心将开发和提供数据培训和资源。在目标4中，我们将确定快速 数据基础设施现代化支持（快速DIMS）的需求，并提供方案资源。在 成功完成拟议的研究，预期成果是集中支持，资源， 并协调HEAL HD2A创新项目的所有数据相关需求。拟议的研究是 创新，因为我们团队的经验将在临床研究和信息学之间架起桥梁 基础设施，为数据收集，管理， HD2A创新项目的报告和管理。这些结果将为 进一步/未来发展阿片类药物过量预防监测，预计将有重大意义。 通过允许快速干预和资源转移来影响过量。这项研究与NIH保持一致 NIDA和HEAL的目标是预防和减轻OUD流行的影响。

PROJECT SUMMARY The multidimensional challenge of opioid overdose prevention requires solutions larger than a single network project. While the HHS and NIH are focusing on developing prevention strategies from numerous perspectives, blending these data will require complex data solutions to move beyond siloes. While we do not know yet how bringing the elements of opioid overdose data together will be most effective, collecting these data in ways that allow for FAIR (Findable, Accessible, Interoperable, Reusable) formatting builds toward that potential. The goal of the HEAL D2A program is to develop opioid overdose surveillance in real time, but it going to take significant combined clinical and informatics knowledge to bring this system together. To accomplish this goal, our proposal is responsive to RFA-DA-22-052 to design flexible and creative informatics solutions for the HEAL Data2Action program (HD2A) network. The WF Data Infrastructure Support Center (DISC)'s highly qualified clinical informatics team will provide direct support, guidance, and assistance to ensure that data infrastructures of the highest quality are produced in the shortest possible time for the HEAL D2A Innovation Projects. Our overall goal as a U24 Data Center is to identify and eliminate data infrastructure barriers (knowledge and technical) to allow successful completion of the HD2A projects. The objective of this proposal is to navigate the expected and unexpected data challenges for the HD2A network, encompassing the Innovation projects to identify tools, provide data support, and deliver training assistance. We will accomplish this objective through successful completion of these phased aims. To support the overall hypothesis of the HEAL D2A network, in Aim 1, the WF DISC's Study Start-up Core will identify and develop data infrastructure support and tools. In Aim 2, WF DISC's Study Conduct Core will work with the HD2A RASC and MERC provide data measurement, analytical, and visualization support and coordination. In Aim 3, The WF DISC's Study Dissemination Core will develop and provide data training and resources. In Aim 4, we will identify rapid data infrastructure modernization support (Rapid DIMS) needs and provide programmatic resources. At the successful completion of the proposed research, the expected outcomes are centralized support, resources, and coordination of all data-related needs for the HEAL HD2A Innovation Projects. The proposed research is innovative because adaptation of our team's experience will bridge clinical research and informatics infrastructure to provide logistical, scientific, oversight, and technical support for data collection, curation, reporting, and management by the HD2A Innovation Projects. These results will provide a strong basis for further/future development of opioid overdose prevention surveillance, which is expected to have a significant impact on overdose by allowing for rapid intervention and pivoting of resources. This research aligns with NIH NIDA and HEAL's goals to prevent and mitigate the impact of the OUD epidemic.