Mechanisms underlying short- and long-term plasticity at the mossy fibre -> CA3 synapse in the hippocampus

突触，脑细胞之间的联系，具有极强的可塑性。它们可以根据所经历的活动变得更强或更弱。众所周知，海马体是大脑中的一种结构，对有意识记忆的形成至关重要。这种结构中突触的可塑性被认为是学习和记忆的基础。因此，了解海马体突触强度变化的机制对我们理解学习和记忆非常重要。该提案描述了一系列旨在确定塑性变化机制的实验。我们希望，通过理解这些机制，我们可以开始理解我们是如何学习和记忆的。

Synapses, the contacts between brain cells, are extremely plastic. They can become stronger and weaker depending on the activity they experience. The hippocampus, a structure in the brain, is known to be critical to the formation of conscious memories. The plastic nature of the synapse in this structure is thought to underlie learning and memory. Understanding the mechanisms that are responsible for the changes in synaptic strength in the hippocampus are therefore important to our understanding of learning and memory. This proposal describes a series of experiments that are designed to determine the mechanisms of plastic changes . We hope, that by understanding these mechanisms, we can start to understand how we learn and remember.