Development of simulated 3-D virtual reality testing for baboon AD/dementia and spatial cognition research

总体摘要 西南国家灵长类动物研究中心（SNPRC）的使命是改善我们的 通过对非人类灵长类动物（NHP）的创新生物医学研究，在全球社会中发挥重要作用。的一种方式 它实现这一目标的方式是为科学家提供全球资源，使他们能够从其专业知识中受益， 非人类灵长类动物群落德克萨斯生物医学研究所（Texas Biomed），一家私营非营利组织 位于德克萨斯州圣安东尼奥的一家研究机构在使用NHP进行生物医学研究方面有着悠久的历史 可以追溯到20世纪50年代由于其成功，德克萨斯生物医学公司被选为西南国家大学的主办单位。 1999年在灵长类动物研究中心。在这样做的过程中，SNPRC成为美国国立卫生研究院资助的最新的国家 灵长类研究中心。SNPRC的重新NIH支持申请强调了这些变化 是对之前P51更新审查的回应。具体来说，有几个 领导层的关键更换和招聘。此外，SNPRC还重组了其内部研究 计划分为两个科学单位，以配合其专业知识和未来的目标。新的传染病， 免疫学和控制（IDIC）科学单位代表了几十年来发展的研究优势， 以灵长类动物为基础的研究，使更多的重视这些领域。它已经利用了这个单位的 成为SARS-CoV-2研究的领导者。与此同时，比较医学与健康 结果（CMHO）科学单位被定位为非人类灵长类动物研究的领导者，最近 重点研究领域包括代谢疾病、神经科学和衰老。两个科学单位 对包括猕猴、狒狒和绒猴在内的多种灵长类动物进行研究， 纳入SNPRC的总体目标，其中包括涉及NHP模型的研究计划 其他NPRC无法提供的人类疾病。SNPRC将继续努力实现其使命， 为了维持几个NHP（NHP）物种的健康和良好特征的繁殖和研究群体， （二）提供广泛的生物医学研究资料，并向科学界提供; 为国家研究界提供灵长类动物研究服务，重点是 技术和能力，其中许多是SNPRC独有的。我们提供这些服务， 增加内部和外部调查人员的合作机会。我们的专业知识， NHPs的种类使我们能够就如何最好地实现 研究项目，从而提高生产力和效率的研究，并加强 （三）维护和加强实体和行政管理， NPRC的基础设施，使其能够更好地为生物医学研究服务。SNPRC经历了重大的 在过去的一年里，行政结构发生了变化。这些变化对效率和 生产力已经很明显; iv）加强对工作人员、学生和来访者的护理和使用培训 五）通过以下方式促进科学和转化医学的进步： 公布与国家卫生保健中心开展的研究成果，并向公众开展教育宣传。

OVERALL ABSTRACT The Mission of the Southwest National Primate Research Center (SNPRC) is to improve the health of our global community through innovative biomedical research with nonhuman primates (NHPs). One way that it achieves this goal is by serving as a global resource to scientists that can benefit from its expertise and nonhuman primate colonies. Texas Biomedical Research Institute (Texas Biomed), a private nonprofit research organization in San Antonio, TX, has a long history of performing biomedical research using NHPs dating back to the 1950s. Because of its success, Texas Biomed was chosen to host the Southwest National Primate Research Center in 1999. In doing so, SNPRC became the newest of the NIH funded National Primate Research Centers. This application for renewed NIH support of the SNPRC highlights the changes made in response to the reviews from the previous P51 renewal. Specifically, there have been several critical replacements and hires in leadership. In addition, SNPRC has restructured its internal research program into two Scientific Units to align with its expertise and future goals. The new Infectious Disease, Immunology and Control (IDIC) Scientific Unit represents research strengths developed over decades of primate-based research to bring greater emphasis to these areas. It is already taken advantage this Unit's expertise to become a leader in SARS-CoV-2 research. Meanwhile the Comparative Medicine and Health Outcomes (CMHO) Scientific Unit is positioned to be a leader in nonhuman primate research in recently emphasized research fields including metabolic disease, neuroscience, and aging. Both Scientific Units perform research with multiple species of primates including macaques, baboons and marmosets and are integrated into the overarching aims of the SNPRC which include research programs involving NHP models of human disease not available at other NPRCs. The SNPRC will continue to work towards its mission by i) To maintain healthy and well-characterized breeding and research colonies of several NHP (NHP) species for biomedical research, and to make them available to the scientific community; ii) To provide broad services in primate research to the national research community with an emphasis on specialized technologies and capabilities many of which are unique to the SNPRC. We provide these services to enhance collaborative opportunities to both internal and external investigators. Our expertise with diverse species of NHPs allows us to contribute ideas and perspectives about how best to accomplish the goals of research projects, thereby increasing the productivity and efficiency of the research, and strengthening the value of the data derived from it; iii) To maintain and to enhance the physical and administrative infrastructure of the NPRC so that it can best serve biomedical research. SNPRC has undergone significant changes in the Administrative structure in the past year. The benefits of these changes to efficiency and productivity are already apparent; iv) To advance training of staff, students, and visitors in the care and use of NHPs in biomedical research; v) To contribute to advances in science and translational medicine via publication of results obtained from research with NHPs and educational outreach to the public.