Enhancing Duke University's Animal Resources

描述(由申请人提供)： 实验动物资源部继续努力升级和提高杜克大学动物资源项目的质量。我们项目的需求支持了400名教师的知识产权，他们使用了超过25个物种，并为大学带来了4.03亿美元的直接资金用于动物相关研究。在过去的几年里，杜克大学投入了大量的资源来建造和装备最先进的基因组科学研究大楼II(GSRB II)，可以容纳19,000个鼠笼，目前正在建设的医学科学研究大楼II(MSRB II)包括10,800平方英尺的新动物空间。GSRB II、MSRB II和最近完成的动物资源改善补助金所产生的势头正在应用于较老的校园动物设施，以继续努力使它们达到适当的标准，增强它们的能力，并改善整个校园内动物的健康状况。杜克建议利用这些NCRR资金来加强目前正在进行的动物资源改进倡议。 这项建议的具体目的是：1)将现有的中央隔膜反渗透净水系统和不锈钢房间分配系统扩展到其余27个目前没有供水或陈旧的动物室；2)按照最近完成的动物设施总体规划翻新医学科学研究大楼I(MSRB I)，作为校园范围内啮齿动物再衍生的核心。建议的MSRB I期翻新工程包括拆除现有的动物房隔离隔间、安装消毒器、重铺所有地面、购置通风的鼠笼架和所需的改装设备。这些目标中的每一个都将有助于增加这两个设施的住房能力，帮助满足不断增加的动物数量的需求。本申请中描述的设备和改进是继续我们的设施现代化，为动物提供最高质量的护理和维持教职员工的研究努力所必需的。

DESCRIPTION (provided by applicant): The Division of Laboratory Animal Resources continues its efforts to upgrade and improve the quality of Duke University's animal resources program. The needs of our program support the intellectual property of 400 faculty who use more than 25 species and bring $403 million of direct funds for animal-related research to the Universtity. Duke has invested significant resources over the last few years to build and equip the state of the art Genome Sciences Research Building II (GSRB II) with capacity for 19,000 mouse cages, and currently has under construction Medical Sciences Research Building II (MSRB II) which includes 10,800 net square feet of new animal space. The momentum engendered by GSRB II, MSRB II and a recently completed Animal Resources Improvement Grant is being applied to older campus animal facilities in a continuing effort to bring(them up to appropriate standards, enhance their capacities and improve the health status of animals campus-wide. Duke proposes utilizing these NCRR funds to augment current animal resource improvement initiatives underway. The specific aims of this proposal are to: 1) extend the existing Central Vivarium reverse osmosis water purification system and stainless steel room distribution systems to the remaining 27 animal rooms currently with no or antiquated watering and; 2) renovate the Medical Sciences Research Building I (MSRB I) in accordance with a recently-completed animal facilities master plan to serve as a campus-wide rodent rederivation core. Proposed MSRB I renovations include removal of existing animal room isolation cubicles, installation of a sterilizer, resurfacing of all floors, acquisition of ventilated rodent cage racks as well as needed rederivation equipment. Each of these aims will also help increase the housing capacity of both facilities, helping meet the need of ever increasing animal populations. The equipment and improvements described in this application are needed to continue the modernization of our facilities, provide the highest quality of care to the animals and sustain the research efforts of the faculty.