Postdoc Training in Translational Research in Neural Injury and Neurodegeneration

描述（由申请人提供）：我们为完成神经病学，神经外科，精神病学，眼科，麻醉，急诊医学或任何其他临床神经科学专业临床培训的医学博士或医学博士提供神经损伤和神经变性转化研究的综合培训计划，并希望在疾病神经生物学的实验室基础上进行转化研究。临床科学家有一种独特的能力，可以根据患者的观察提出新的科学问题，并且可以与博士科学家和医疗保健提供者进行沟通和合作。该项目建立在师徒关系的基础上，由两位经验丰富的教师培训师指导学员的研究发展。将选择导师为受训者提供补充经验。受训者将有机会进入宾夕法尼亚大学教师“核心”小组的至少22个实验室，但也可以在其他实验室进行培训。实习研究必须是合作的，提出至少两个群体相关的问题。这个为期2年的项目将专注于急性和慢性神经退行性疾病和病症的神经保护，包括中风；脑、脊髓损伤；阿尔茨海默病、帕金森病和运动神经元疾病；癫痫;视网膜变性;抑郁症;行为障碍;自闭症。培训将重点放在实验室研究上，培训项目旨在了解遗传、分子和细胞病理生理学以及预防、治疗或治愈策略的发展。教学培训将包括：大学疾病神经生物学综合课程的课程和临床试验方法学、拨款准备、统计学、生物伦理学、以患者为导向的研究和新药开发的研讨会。该项目将从两名受训者开始，在两年内增加到五名。该计划的一个独特之处在于，在临床培训结束之前，潜在的受训者将知道他们被该计划接受。这将使受训者能够利用实习期间的时间，进行研究和研究相关经验的积累，从而对这一阶段的专业发展进行规划，最终达到在撰写k奖申请书之前扩大所获得的培训总量的效果。预计完成该课程的学员将在独立研究经费方面具有很强的竞争力，将成为学术医疗中心的教员，并将从事疾病神经生物学的转化研究。相关性：我们建议教授医生进行神经系统疾病病因的实验室研究。更好的理解将导致新的治疗方法的发展。

DESCRIPTION (provided by applicant): We propose an integrative training program in translational research in neural injury and neurodegeneration for MDs or MD-PhDs who finish clinical training in Neurology, Neurosurgery, Psychiatry, Ophthalmology, Anesthesia, Emergency Medicine or any other clinical neuroscience specialty, and desire academic careers in laboratory-based translational research in the Neurobiology of Disease. Clinician-scientists have a unique ability to ask new scientific questions inspired by patient observations, and are singularly situated to communicate and collaborate with both PhD scientists and health care providers. The program is built around mentoring relationships in which two experienced faculty trainers guide a trainee's research development. Mentors will be chosen to offer complementary experience to the trainee. Trainees will have access to a minimum of 22 laboratories within the "core" group of Penn faculty, but could train in other laboratories as well. Trainee research must be collaborative, asking questions relevant to at least two groups. The 2-year program will focus on neuroprotection for acute and chronic neurodegenerative diseases and conditions, including stroke; brain and spinal cord injury; Alzheimer's, Parkinson's and motor neuron diseases; epilepsy; retinal degeneration; depression; behavioral disorders; autism. Training will focus heavily on laboratory research, with trainee projects directed toward understanding the genetic, molecular and cellular pathophysiology and the development of strategies for prevention, treatment, or cure. Didactic training will include: coursework in the University's comprehensive Neurobiology of Disease curriculum and workshops in clinical trial methodology, grant preparation, statistics, bioethics, patient-oriented research, and new drug development. The program would begin with 2 trainees, growing to 5 within 2 years. A unique feature of the proposed Program is that prospective trainees will know of their acceptance into the Program well before their clinical training ends. This will allow trainees to plan for this stage of their professional development by taking advantage of the time during residency to gain research, and research-related experience, with the final effect of expanding the total amount of training they will have acquired before writing their K-award proposal. It is expected that trainees who complete this program will be very competitive for independent research grant funding, will become faculty members at academic medical centers, and will pursue careers in translational research in the neurobiology of disease. Relevance: We propose to teach physicians to conduct laboratory research into causes of neurological diseases. A better understanding will lead to the development of new treatments and cures.