Cooperative Breast Cancer Tissue Resource

合作乳腺癌组织资源(CBCTR)是由美国国家癌症研究所赞助的 为分子标记研究提供石蜡固定的标本。Kaiser Permanente 俄勒冈州波特兰(KPNW)自1994年以来一直是该项目的积极成员，并寻求继续 这一作用将在下一个资助期发挥作用。 CBCTR已经收集了9000多个乳腺癌组织样本，并将其与人口统计学联系起来， 来自癌症登记和医疗记录的临床和结果变量。病理材料可以是 以个别患者首次手术后的切片或组织形式提供 结合数百个样本的组织核心的微阵列。研究人员可以申请这种材料 以实现候选预后标记物的测试和/或验证。一项独立研究 评价小组评估这些请求的科学价值和技术可行性。协调 由四个地点的首席调查员组成的CBCTR委员会审查这些请求 对于资源的适当性。考虑因素包括成功的可能性、对工作负载的影响 以及对资源的持续运营和可用性的影响。 KPNW捐赠了2400多个标本，分发了数百个组织样本 满足社区研究人员的要求。此外，KPNW的调查人员和工作人员 帮助制定和修改日常运作中使用的程序、文件和 关于CBCTR的介绍，在科学会议上的展示和科学领域的宣传努力 社区。随着CBCTR接近更广泛地使用其标本，特别是TMA的目标， KPNW随时准备用我们档案中更多以前未经检查的标本来补充收藏。

The Cooperative Breast Cancer Tissue Resource (CBCTR) is sponsored by the National Cancer Institute to provide acrchival, paraffin-fixed specimens for the study of molecular markers. Kaiser Permanente, Portland, Oregon (KPNW) has been an active member of this project since 1994 and seeks to continue in this role in the next funding period. The CBCTR has collected over 9000 specimens of breast cancer tissue and linked it to demographic, clinical and outcome variables from cancer registries and medical records. The pathological material can be supplied as sections of blocks from the initial surgery undergone by individual patients or as a Tissue Microarray that combines tissue cores from hundreds of specimens. Researchers may apply for this material to enable the testing and/or validation of candidate prognostic markers. An independent Research Evaluation Panel evaluates these requests for scientific merit and technical feasibility. The Coordinating Committee of the CBCTR, comprising the Principal Investigators of the four sites, reviews these requests for appropriateness for the Resource. Considerations include the likelihood of success, impact on workloads and effect on the continuing operation and usability of the Resource. KPNW has contributed over 2400 specimens and distributed hundreds of tissue samples in the process of filling requests from researchers in the community. In addition, KPNW investigators and staff have contributed to the development and modifications of the procedures used in daily operations, to papers and presentations about the CBCTR, to displays at scientific meetings and to publicity efforts in the scientific community. As the CBCTR approaches its goal of wider use of its specimens, particularly of the TMAs, KPNW stands ready to replenish the collection with more, previously unexamined specimens from our files.