Instrumentation for Creating Biological Stents and Occlusions

描述(由申请人提供)：拟议研究计划的长期目标是提供所需的器械，以安全地扩张或闭塞位于身体几乎任何位置的管道、导管或血管的管腔，实施微创手术。这些手术不需要将外来材料引入体内，这些材料有时会导致严重的副作用，在许多情况下，可以在门诊的基础上进行手术。虽然产生的扩张和闭塞可能会持续很长时间，但如有必要，可以重复这些程序。该仪器将包括工作在5800 75 MHz频段的微波发生器，以及设计用于在不同解剖位置产生生物支架或闭塞的微波导管。具体目标是制造一台5800 MHz固态发生器的原型，以及用于扩大胆管和胰管管腔以及周围动脉管腔的微波导管，用于闭塞静脉曲张。与公共卫生相关：拟议中的计划将产生的器械将使医生能够安全地扩大许多因疾病而变窄的重要人体管道、管道和血管的直径，或在有时必要时关闭它们。医生通常能够在门诊的基础上做到这一点，而不必将异物引入体内，这些异物有时会导致严重的副作用。

DESCRIPTION (provided by applicant): The long-term objectives of the proposed research program are to provide the instrumentation required to perform minimally invasive procedures for safely dilating or occluding the lumens of canals, ducts or vessels that are located almost anywhere in the body. The procedures will not require the introduction of foreign materials into the body, materials that can sometimes cause serious side effects, and in many cases it will be possible to perform them on an outpatient basis. While the dilations and occlusion that are produced are likely to be long lasting, the procedures can be repeated if necessary. The instrumentation will consist of microwave generators operating in the 5800 75 MHz frequency band, and microwave catheters designed to produce biological stents or occlusions in various anatomical locations. The specific aims are to fabricate a prototype 5800 MHz solid-state generator, and microwave catheters designed for enlarging the lumens of bile and pancreatic ducts and of peripheral arteries, for occluding varicose veins. PUBLIC HEALTH RELEVANCE: The instrumentation that would result from the proposed program would enable physicians to safely enlarge the diameter of many important human canals, ducts, and vessels that are narrowed by disease, or to close them as is sometimes necessary. The physicians will be often be able to accomplish this on an outpatient basis and without having to introduce foreign materials into the body, materials that can sometime cause serious side effects.