Sodium Nitrite Supplementation for Improving Physiological Function in Patients with Chronic Kidney Disease

摘要 获奖者：马修·J·罗斯曼博士，综合系助理研究教授 科罗拉多大学博尔德分校的生理学。通过他的K01奖项，罗斯曼博士的目标是测试 每日补充无机硝酸盐改善高血压病患者血管、运动和认知功能的效果 慢性肾脏病(CKD)患者。他的直接目标是获得研究培训和 需要专业技能才能成为一名独立的、由外部资助的调查员。他的长期目标是 是建立一个研究计划，重点是确定改善血管、运动的新干预措施 和认知功能，以降低心血管疾病(CVD)和其他CKD合并症的风险。 职业发展计划：罗斯曼博士的职业发展计划包括：1)获得新的 与拟议的研究计划相关的研究技能；2)肾脏生理学、慢性肾脏病、运动和 认知功能、临床试验和生物统计学；3)专业技能发展。 环境：罗斯曼博士的培训计划的环境非常好。罗斯曼医生的初诊 导师Douglas Seals博士和他的共同导师Michel Chonchol博士是国际公认的、由NIH资助的 有成功指导记录的科学家。Chonchol医生是一名经董事会认证的肾病医生， 安舒茨大学肾脏疾病和高血压科临床研究主任。Dr。 罗斯曼的指导团队还包括生物统计学、运动和认知功能方面的专家。 CKD；硝酸盐/亚硝酸盐/NO生物学和通过补充硝酸盐改善生理功能。 研究：心血管疾病是CKD患者的主要死亡原因。CKD患者心血管疾病风险增加在很大程度上 可归因于血管功能障碍，主要是血管内皮功能障碍和大的弹性动脉 变得僵硬。运动和认知功能减退在慢性肾脏病中也很常见，并增加残疾的风险 和CKD病死率。用无机硝酸盐靶向硝酸盐-亚硝酸盐-一氧化氮(NO)途径是一种 提高一氧化氮和改善多个生理领域的新颖、安全和创新的方法 慢性肾脏病的功能障碍。罗斯曼博士的研究正在测试补充富含硝酸盐的甜菜根的效果 果汁改善慢性肾脏病患者血管、运动和认知功能的随机临床试验。 需要研究连续性补充：罗斯曼博士正在他的K01的最后两年 并因此过渡到完全的研究独立。罗斯曼医生将在一月份迎来一个孩子 2023年的。以保持他的研究效率，并允许罗斯曼博士将他的时间投入到对 在生物医学研究方面保持竞争力，罗斯曼博士要求为一项临床研究提供工资支持 协调人1年。临床研究协调员将负责关键的后勤、技术和管理工作 罗斯曼博士K01支持的临床试验的责任。罗斯曼博士将直接监督 临床研究协调员，同时致力于关键的专业发展活动。

ABSTRACT AWARDEE: Matthew J. Rossman, Ph.D., is an Assistant Research Professor in the Department of Integrative Physiology at the University of Colorado (CU) Boulder. With his K01 award, Dr. Rossman aims to test the efficacy of daily inorganic nitrate supplementation for improving vascular, motor and cognitive function in patients with chronic kidney disease (CKD). His immediate goal is to obtain the research training and professional skills needed to transition to an independent, extramurally funded investigator. His long-term goal is to establish a research program with a focus on identifying novel interventions that improve vascular, motor and cognitive function to reduce the risk of cardiovascular disease (CVD) and other comorbidities in CKD. CAREER DEVELOPMENT PLAN: Dr. Rossman’s career development plan consists of: 1) acquiring new research skills associated with the proposed research plan; 2) training in renal physiology, CKD, motor and cognitive function, clinical trials and biostatistics; and 3) professional skill development. ENVIRONMENT: The environment for Dr. Rossman’s training plan is outstanding. Dr. Rossman’s primary mentor Dr. Douglas Seals and his co-mentor Dr. Michel Chonchol are internationally recognized, NIH-funded scientists with strong records of successful mentoring. Dr. Chonchol is a board-certified nephrologist and Director of Clinical Research in the Division of Renal Diseases and Hypertension at CU Anschutz. Dr. Rossman’s mentorship team also includes experts in biostatistics; motor and cognitive function in patients with CKD; and nitrate/nitrite/NO biology and improving physiological function via nitrate supplementation. RESEARCH: CVD is the leading cause of death in patients with CKD. Increased CVD risk in CKD is largely attributable to vascular dysfunction, primarily vascular endothelial dysfunction and large elastic artery stiffening. Reduced motor and cognitive function are also common in CKD and increase the risk of disability and mortality in CKD. Targeting the nitrate-nitrite-nitric oxide (NO) pathway with inorganic nitrate represents a novel, safe and innovative approach for enhancing NO and improving multiple domains of physiological dysfunction in CKD. Dr. Rossman’s research is testing the efficacy of supplementation with nitrate-rich beetroot juice for improving vascular, motor and cognitive function in patients with CKD in a randomized clinical trial. NEED FOR RESEARCH CONTINUITY SUPPLEMENT: Dr. Rossman is in the final two years of his K01 award and, as such, transitioning to full research independence. Dr. Rossman is expecting a child in January of 2023. To sustain his research productivity and allow Dr. Rossman to devote his time to activities critical for remaining competitive in biomedical research, Dr. Rossman is requesting salary support for a clinical research coordinator for 1 year. The clinical research coordinator will handle key logistical, technical and administrative responsibilities for Dr. Rossman’s K01-supported clinical trial. Dr. Rossman will provide direct oversight of the clinical research coordinator while devoting his time to critical professional development activities.