MAINTENANCE OF IMMUNOLOGIC MEMORY TO MEASLES VACCINE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：建立恒河猴对麻疹疫苗的长期免疫记忆动物模型。麻疹病毒在恒河猴身上是致病的，感染的猴子的免疫反应与人类相似。给猴子接种麻疹减毒活疫苗，可保护它们在受到致病性麻疹病毒攻击后免受全身感染和疾病。这一提议有两个目标和假设。1.记忆B细胞和T细胞在血液和体内组织中的循环与幼稚细胞不同，组织中淋巴细胞的循环和滞留模式与最初的免疫途径有关。2.在长期记忆中持续存在的记忆B细胞和T细胞的水平取决于在初级免疫反应中产生的病毒抗原的数量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The goal of this proposal is to establish an animal model of long-term immunologic memory to measles vaccine in the rhesus monkey. Measles virus is pathogenic in rhesus monkeys and the immune responses of infected monkeys are similar to those in humans. Vaccination of monkeys with live-attenuated measles vaccine protects them from systemic infection and disease after challenge with pathogenic measles virus. There are two aims and hypotheses for this proposal. 1. Memory B and T cells circulate in the blood and through body tissues differently than do naive cells, and patterns of lymphocyte circulation and retention in tissues are related to the initial route of immunization. 2. The levels of memory B and T cells that persist during long-term memory are determined by the amount of viral antigen produced during the primary immune response.