HIGHLY ATTENUATED SIV VIF DNA VACCINES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：慢病毒辅助基因vif是慢病毒复制所必需的。Vif通过靶向细胞胞苷脱氨酶APOBEC 3G进行蛋白质体降解来抑制病毒粒子掺入该细胞胞苷脱氨酶。vif缺失的病毒可能在宿主中持续存在，尽管其水平极低，并且仅限于特定组织或APOBEC 3蛋白表达降低的细胞亚群。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The accessory gene vif of lentiviruses is required for efficient viral replication. Vif inhibits virion incorporation of a cellular cytidine deaminase, APOBEC3G, by targeting this cellular protein for proteosomal degradation. A vif-deleted virus may be persistent in the host, although at extremely low levels and restricted to specific tissues or cell subsets with reduced expression of APOBEC3 proteins.