Mental Health Conferences: Comparative & Primate Studies

描述（由申请人提供）：目前，神经科学拥有将基础科学发现快速和前所未有地转化为心理健康疾病有效治疗干预措施的前景。这部分是由于动物模型的成功使用，如啮齿动物和非人类灵长类动物，以阐明复杂的脑回路，这些脑回路是情感和认知行为的基础，这些行为在主要的精神健康障碍中受到最大的影响，包括情绪障碍，精神分裂症，焦虑症和自闭症。然而，我们对精神健康障碍的理解的新进展可能会通过协调一致的努力来更好地整合这些研究工作。这对于使用非人灵长类动物的研究尤其如此，因为它们代表了有限的资源，并且研究费用高昂。该补助金提议汇集一个跨学科的科学家核心小组，选择包括使用人类，非人类灵长类动物和啮齿动物的研究人员，涵盖一系列心理健康重点领域，并具有一系列技术的专业知识，以举办一系列会议，以实现以下具体目标：（1）确定非人类灵长类动物研究中需要进一步关注的精神疾病根源问题，以便最大限度地从每次研究中获得信息，（2）确定因缺乏信息或技术困难而阻碍临床相关动物研究发展的研究领域，并重点解决这些问题，（3）为研究精神疾病根源的研究界带来新技术和新视角，重点是脑成像，遗传学和神经发育，以及（4）向更广泛的科学界传播有关精神疾病根源研究中有用的研究策略的新信息。该系列会议将重点关注四个心理健康领域：抑郁症，焦虑症，精神分裂症和自闭症;关注遗传学和脑成像的新技术;并将发展视角融入所有领域。该系列会议将包括每年一次核心小组会议和两次更广泛的会议，为期五年。会议的产品将是在广泛的实验室中共享信息和专业知识，一个公共领域的交互式网站，可以访问共享信息和专业知识，以及由与会者撰写的关于精神卫生领域转化研究的编辑卷。

DESCRIPTION (provided by applicant): At this time, neuroscience holds the prospect for rapid and unprecedented translation of basic science findings into effective therapeutic interventions for mental health diseases. This is due, in part, to the successful use of animal models, such as rodents and nonhuman primates, to elucidate the complex brain circuitry that underlies the affective and cognitive behaviors that are most impacted in the major mental health disorders, including mood disorders, schizophrenia, anxiety disorders, and autism. However, new advances in our understanding of mental health disorders could likely be leveraged by a concerted effort to better integrate these research efforts. This is particularly true for studies using nonhuman primates, in that they represent a limited resource, and the studies are costly. This grant proposes to bring together an interdisciplinary Core Group of scientists selected to include investigators using humans, nonhuman primates and rodents in their research, covering a range of mental health focus areas, and with expertise across a range of technologies to hold a series of conferences to undertake the following specific aims: (1) define issues in nonhuman primate studies of the roots of mental illness that need further attention in order to maximize information gained from each study, (2) define research areas in which the development of clinically relevant animal studies has been hindered by lack of information or technical difficulties, and focus on resolving these issues, (3) bring new technologies and perspective to the research community studying the roots of mental illness, focusing on brain imaging, genetics and neurodevelopment, and (4) disseminate new information about useful research strategies in studies of the roots of mental illness to the broader scientific community. This conference series will focus on four mental health areas: depression, anxiety, schizophrenia, and autism; focus on new technologies in genetics and brain imaging; and integrate a developmental perspective in all areas. The conference series will comprise 1 Core Group meeting and 2 broader conferences each year for a period of 5 years. Products of the conference will be shared information and expertise across a wide range of laboratories, an interactive web site in the public domain that allows access to shared information and expertise, and an edited volume on translational research in the field of mental health written by conference participants.