Specimen Core

该项目将使用人类膀胱癌标本和细胞系进行翻译。 旨在改善人类膀胱癌的早期发现、预防和治疗的研究。 样本芯将提供给M. D.安德森癌症中心和其他合作机构 从膀胱癌患者的高质量组织样本诊断，治疗， 在我们的机构里被跟踪。已经建立了组织的标准化和集中化程序 样本的采购、质量控制、处理、储存和分发给个体研究者 并将确保根据样本制定的指导方针最佳地使用样本 以马克思标本中心设施的功能包括标本采集、处理、储存， 组织病理学审查、病理学和临床数据库的管理以及 向项目研究人员提供特征良好的标本。计算机化的数据库包含了 所有样本的病理学和临床记录，包括储存和分发给个体研究者的样本，以及 包括单个SPORE项目的结果，以促进核心对需求的有效响应 在这个SPORE和合作机构的研究人员。这些资源也将用于 未来通过NCI早期检测和研究网络分发。两名病理学家， 膀胱癌和标本核心操作的所有方面，包括组织病理学评价和 质量控制，将共同指导该设施。该核心还将维持一个细胞系库，用于分发给 这个SPORE的成员和其他调查人员。这个集中的综合样本核心设施将 为本SPORE提案中概述的多学科和转化研究项目提供支持。 样本核心的具体目标如下。具体目标1：提供技术服务， 对SPORE中概述的临床和研究项目中使用的所有临床标本进行病理学审查 提议具体目标2：维持尿路上皮癌标本、正常膀胱组织、 相关的标本。具体目标3：从M. D.安德森癌症 中心档案和来自转诊机构的福尔马林固定和石蜡包埋组织。具体目标4： 保持和扩大创新和独特的组织资源。具体目标5：保持全面的 关系数据库

The projects of this SPORE will use human bladder cancer specimens and cell lines for translational research directed toward improving the early detection, prevention, and treatment of human bladder cancer. The Specimen Core will provide investigators at M. D. Anderson Cancer Center and other collaborating institutions with high-quality tissue samples from patients with bladder cancer diagnosed, treated, and followed at our institution. Standardized and centralized procedures have been established for tissue procurement, quality control, and processing, storage, and distribution of samples to individual investigators and will ensure optimal use of the samples according to the guidelines established by the Specimen Committee. Functions of the Specimen Core facility will include specimen procurement, processing, storage, histopathologic review, and management of both pathological and clinical databases as well as distribution of well-characterized specimens to project investigators. The computerized database contains both pathological and clinical records of all samples, both stored and distributed to individual investigators, and includes the results of individual SPORE projects to facilitate the efficient response of the core to the needs of investigators in this SPORE and at collaborating institutions. These resources will also be available for future distribution through the NCI Early Detection and Research Network. Two pathologists with expertise in bladder cancer and in all aspects of the Specimen Core operations, including histopathologic evaluation and quality control, will co-direct the facility. This Core will also maintain a bank of cell lines for distribution to the members of this SPORE and other investigators. This centralized comprehensive Specimen Core facility will provide support for the multidisciplinary and translational research projects outlined in this SPORE proposal. The specific aims of the Specimen Core are as follows. Specific Aim 1: Provide technical services and pathology review of all clinical specimens utilized in the clinical and research projects outlined in the SPORE proposal. Specific Aim 2: Maintain a repository of urothelial carcinoma specimens, normal bladder tissue, and related specimens. Specific Aim 3: Retrieve paraffin-embedded tissue from M. D. Anderson Cancer Center archives and formalin-fixed and paraffin-embedded tissue from referring institutions. Specific Aim 4: Maintain and expand innovative and unique tissue resources. Specific Aim 5: Maintain a comprehensive relational database.