MicroRNA regulation of fear-related memory

情感创伤经历会被很好地记住，在某些情况下，频繁地提醒这些事件会导致与恐惧相关的焦虑症的发展，如恐惧症或创伤后应激障碍（PTSD）。本提案中概述的实验将研究一种新的基因调控表观遗传机制如何通过称为灭绝的过程促进从恐惧记忆的检索到其抑制的过渡。

Emotionally traumatic experiences are well remembered and, in some instances, frequent reminders of these events can lead to the development of fear-related anxiety disorders such as phobia or post-traumatic stress disorder (PTSD). The experiments outlined in this proposal will examine how a novel epigenetic mechanism of gene regulation contributes to the transition from the retrieval of a fear memory to its inhibition through a process called extinction.