MECHANISMS OF EXERCISE INTOLERANCE AND EFFECTS OF TRAINING IN CHILDREN WITH HEAR

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 本项目将招募6 ~ 13岁的儿童，包括Fontan手术后40例单心室儿童，心脏移植后40例儿童，以及40例健康儿童作为对照。入学的儿童将在夏季随机参加为期6周的运动训练计划或计算机课程。受试者将在运动训练前后在门诊GCRC接受一次全天访视。将进行营养评估、DEXA扫描、大腿MRI、超声心动图、肺功能检查和踏车运动试验。将抽取血液进行儿茶酚胺和细胞因子测定。家长填写两份问卷。GCRC访视后，受试者将佩戴活动监测器2周。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will recruit children 6 to 13 years of age, including 40 children with single ventricle after the Fontan operation, 40 children after heart transplant, and 40 healthy children as controls. Enrolled children will be randomized to a 6-week exercise training program or computer class in the summer. Subjects will have one full-day visit to the outpatient GCRC before and after the exercise training. Nutrition assessment, DEXA scan, MRI of thigh, echocardiogram, pulmonary function test and cycle ergometer exercise test will be performed. Blood will be drawn for catecholamine and cytokine assays. The parents will fill out two questionnaires. After GCRC visit, the subjects will wear an activity monitor for 2 weeks.