WHITE MATTER STRUCTURE/FUNCTION IN DIABETES

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的长期目标是确定糖尿病的影响和强化治疗对人体体内脑代谢和功能的低血糖后果，以确定糖尿病患者是否发生白色物质微结构变化。在目前的实验中，我们打算测试的假设，长期存在的1型糖尿病患者将有较低的分数各向异性的措施比健康志愿者匹配的性别和年龄，这种分数各向异性的减少将与神经认知功能的异常。为了确定适当的样本量来研究这一假设，我们现在建议进行一个试点项目，其中5例1型糖尿病患者与5例年龄和性别匹配的对照组进行比较。本提案的具体目的是收集支持NIH应用的试点数据，旨在确定长期存在的1型糖尿病受试者是否存在白色物质结构异常，这些结构异常可通过3特斯拉扩散张量成像检测到，并与神经认知功能异常相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-range goal of this project is to determine the effects of diabetes and the hypoglycemic consequences of intensive therapy on in vivo brain metabolism and function in humans to determine whether white matter microstructural changes occur in patients with diabetes. In the current experiment we intend to test the hypothesis that patients with long standing type 1 diabetes will have lower measures of fractional anisotropy than will healthy volunteers matched for gender and age and this reduction in fractoinal anisotropy will correlate with abnormalties in neurocognitive function. To determine the appropriate sample size to study to address this hypothesis, we now propose to perform a pilot project in which five subjects with type 1 diabetes are compared to five age and gender matched control subjects. The specific aim of this proposal is to collect pilot data that will support a NIH application with the aim of determining whether the subjects with long standing type 1 diabetes mellitus have structural abnormalities in white matter that can be detected by diffusion tensor imaging at 3 Tesla and correlated with abnormalites in neurocognitive function.