CROSS-SECTIONAL AND LONGITUDINAL STUDY OF ENDOTHELIAL FUNCTION BY BRACHIAL FLOW-

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 高效抗逆转录病毒治疗(HAART)对人类免疫缺陷病毒-1(HIV)相关疾病的改善令人印象深刻。然而，药物治疗可能会增加心脏病的风险。出现高胆固醇和血管功能异常可能会导致这种风险。通过研究各种HIV感染者，包括HAART和NOT，我们建议建立在治疗的不同阶段导致血管功能异常最重要的变量。 主要目的是评估在长期治疗期间报告的内皮功能障碍是否主要是与脂代谢紊乱的发展相关的高血胆固醇和胰岛素抵抗的结果。这项研究将是观察性的，不会具体说明艾滋病毒受试者将接受什么治疗。包括横截面组件和纵向组件。被纳入横断面研究的药物未成熟的受试者也有资格接受纵向评估。纵向研究将主要是探索性的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Highly active antiretroviral treatment (HAART) results in impressive improvement in human immunodeficiency virus-1 (HIV)-related disease. However, drug treatment may increase the risk of heart disease. Developing high blood cholesterol and abnormal blood vessel function may cause this risk. By studying a variety of subjects with HIV infection, both on HAART and not, we propose to establish the variables that are most important at causing abnormal blood vessel function at various stages of treatment. The primary objective is to assess whether the endothelial dysfunction that has been reported during prolonged treatment is primarily the result of the high blood cholesterol and insulin resistance that is associated with the development of lipodystophy. The study will be observational in nature and will not specify what HIV treatment subjects will receive. Cross-sectional and longitudinal components are included. Drug-naive subjects who are enrolled into the cross-sectional study may also be eligible for the longitudinal evaluations. The longitudinal study will primarily be exploratory in nature.