PAROXETINE EFFECT ON RESPONSE TO MENTAL STRESS DURING CIGARETTE SMOKING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 （B） 本研究评估了1个月对帕罗西汀治疗对吸烟者在吸烟后立即进行的2项精神应激任务期间心血管反应和主观不适的影响。 每个受试者接受一个月的帕罗西汀或安慰剂，之后他们返回GCRC进行访问，在访问期间测量心血管反应，同时执行两项预期会导致一些精神压力的任务。这些任务包括做一个简短的演讲和执行心算任务。 在接下来的一个月里，受试者接受替代治疗，之后再次测量对压力任务的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. B) This study is assessing the effect of 1 month of paraoxtine treatment on cardiovascular response and subjective discomfort during 2 mental stress tasks in smokers immediately after smoking a cigarette. Each subject receives one month of either paroxetine or placebo after which they return to the GCRC for a visit during which cardiovascular response is measured while performing two tasks expected to result in some mental stress. These tasks consist of giving a short speech and performing a mental arithmetic task. For the following month, subjects receive the alternate treatment after which response to the stress tasks is measured again.