EFFECTS OF TOTAL SLEEP DEPRIVATION AND RECOVERY SLEEP ON BRAIN FUNCTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目标1：研究健康志愿者在完全睡眠剥夺（total sleep deprivation，TSD）前、中、后不同时间点的认知功能时脑局部血氧水平依赖性（blood oxygen level dependent，BOLD）对比度的变化。 目的2：研究TSD和一天中的时间对认知需求的大脑BOLD反应的联合作用。 目标3：评估随着任务时间的增加，大脑对认知需求的BOLD反应的变化，并确定任务时间如何与TSD相互作用以影响大脑反应。 目的4：确定1或2个晚上的恢复睡眠是否逆转TSD对认知需求的大脑BOLD反应的影响。 目的5：研究重复认知测试对本研究中使用的脑功能磁共振成像测量的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aim 1: To determine regional brain changes in blood oxygen level dependent(BOLD) contrast during cognitive performance at several time points before, during and after 62 hours of total sleep deprivation (TSD) in healthy volunteers. Aim2: To examine the joint effects of TSD and time of day on cerebral BOLD response to cognitive demands. Aim3: To evaluate changes in cerebral BOLD response to cognitive demands with increasing time on task and to determine how time on task interacts with TSD to influence cerebral response. Aim4: To determine if 1 or 2 nights of recovery sleep reverse the effects of TSD on cerebral BOLD response to cognitive demands. Aim 5: To examine the effects of repeated cognitive testing on the FMRI measures of brain function used during this study.