EFFICACY OF SPINAL KETOROLAC TO REDUCE EXPERIMENTAL PAIN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究正在进行，因为疼痛是一个重要的问题，为患者的各种医疗问题，并在手术或创伤性损伤。目前可用的止痛药可能无法缓解所有类型的疼痛，或者只能在产生副作用和潜在并发症的剂量下缓解疼痛。本研究中的药物可能在更好地治疗疼痛方面发挥作用。本研究的目的是观察一剂酮咯酸（非麻醉性止痛药），经脊柱给药（注入脊柱附近背部的液体中）是否对我们暴露于少量UV-B辐射（轻度晒伤）的小面积皮肤的疼痛或不适有任何影响。 正在研究的药物是FDA批准的药物;但是，我们正在IND 62，179下进行这项研究，因为我们通过与其适应症不同的途径给药。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research study is being done because pain is a significant problem for patients with a variety of medical problems and following surgery or traumatic injury. Currently available pain medications may not relieve all types of pain or may relieve pain only at doses that produce side effects and potential complications. The medication in this study may have a role in better treatment of pain. The goals of this study are to see if a dose of ketorolac (non-narcotic pain reliever), given spinally (given into the fluid in the back near the spine) has any effect on pain or discomfort from a small area of skin that we will expose to a small amount of UV-B radiation (a mild sunburn). The medication being studied is an FDA approved medication; however, we are conducting this study under IND 62,179 because we are administering the medication by a different route than it is indicated for.