NUTRITION SUPPORT IN PEDIATRIC STEM CELL TRANSPLANTATION - A RCT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目的/目标： 接受干细胞移植的儿童通常需要肠外营养，以提供足够的热量和蛋白质，由于严重的粘膜炎和其他胃肠道并发症的准备方案。 准确提供能量可以减少与过度喂养或喂养不足相关的并发症。 我们假设SCT期间身体成分的变化影响REE，并且这些患者的标准营养管理方法可能导致过度喂养。 我们提出了一项前瞻性、随机对照试验，将标准营养支持方法的营养效果与通过间接热量测定法测量的提供能量摄入以完全满足静息能量消耗的方法进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims/Objectives: Children undergoing stem cell transplantation often require parenteral nutrition to provide adequate calories and protein due to severe mucositis and other gastrointestinal complication of the preparative regimen. Accurate provision of energy may reduce complications related to overfeeding or underfeeding. We hypothesize that changes in body composition during SCT affect REE, and that the standard approach to nutritional management of these patients may lead to overfeeding. We propose a prospective, randomized controlled trial to compare the nutritional effects of the standard method of nutritional support with an approach in which energy intake is provided to exactly meet resting energy expenditure as measured by indirect calorimetry.