TREATMENT OF UNSUSTAINED HYPERGLYCEMIA IN PATIENTS WITH CYSTIC FIBROSIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 现有文献表明，伴有胰岛素缺乏和糖耐量受损的囊性纤维化患者的发病率高于正常糖耐量的囊性纤维化患者。肺功能恶化和体重减轻被认为与糖耐量受损和胰岛素缺乏伴或不伴囊性纤维化的患者的分解代谢状态有关。病例报告显示，血糖水平异常的囊性纤维化患者在接受胰岛素替代治疗后，体重和肺功能都得到了改善。这项研究的目的是客观地测量胰岛素治疗前后代谢的变化，以及它与改善肺功能和增加体重的可能关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Current literature indicates that cystic fibrosis patients with insulin deficiency and impaired glucose tolerance have an increased morbidity compared to the normal glucose tolerant CF patients. Worsening pulmonary function and weight loss is thought to be related to the catabolic state that is seen in patients with impaired glucose tolerance and insulin deficiency with or without cystic fibrosis. Case reports have shown that cystic fibrosis patients with abnormal glucose levels who do not have diabetes had improvement in both weight and pulmonary function with insulin replacement therapy. The goal of this study is to objectively measure changes in metabolism before and after initiation of insulin treatment and its possible relation to improved pulmonary function and increase weight.