CREATINE1

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们感兴趣的是人类大脑中线粒体功能改变的代谢影响，这种影响可能发生在使用肌酸等补充剂时。多年来，口服肌酸一直被用作主要用于运动训练的膳食补充剂；然而，大量证据表明，它也可能有利地影响大脑功能(例如，它已被证明可以改善认知能力)。在这个项目中，建议在补充肌酸的同时对健康受试者和癫痫患者进行研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in the metabolic effects of altered mitochondrial function in the human brain, which may occur with utilization of supplements such as creatine. Oral creatine has been used for many years as a dietary supplement primarily for athletic training; however considerable evidence has accumulated that it may also favorably affect cerebral function (for example, it has been shown to improve cognitive performance). In this project, it is proposed that healthy subjects and epilepsy patients will be studied while on creatine supplementation.