ATN 021B: PREVALENCE OF MORPHOLOGIC AND METABOLIC ABNORMALITIES IN HIV INFECTED

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项横断面调查，旨在评估感染艾滋病毒的年轻男性中形态和代谢异常的患病率和严重程度，并评估与这些异常相关的药物和非药物因素。这项研究旨在评估感染艾滋病毒和未感染艾滋病毒的年轻男性在糖代谢、血脂、乳酸、身体成分和骨密度方面是否存在显著差异。此外，这项研究将评估接触特定类别的抗逆转录病毒药物是否与感染艾滋病毒的年轻男性的代谢和形态异常有关。这项研究包括一次性收集健康和病史数据，采集血液和尿液样本，以及身体评估。这项研究将阐明进一步深入研究的必要性，以了解基于蛋白酶抑制剂的疗法和基于非核苷逆转录酶抑制剂的疗法对年轻男性的病理生理影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a cross-sectional survey designed to evaluate the prevalence and severity of morphologic and metabolic abnormalities in HIV-infected young men and to assess the drug and non-drug factors related to these abnormalities. This study is designed to assess whether there exist significant differences in glucose metabolism, lipids, lactate, body composition, and bone density between HIV-infected and -uninfected young men. Furthermore, this study will evaluate whether exposure to specific classes of antiretroviral medications is associated with metabolic and morphologic abnormalities among HIV-infected young men. The study involves a one-time collection of health and medical history data, blood and urine specimen collection, and physical assessments. This study will elucidate the need for a further in-depth study to understand the pathophysiological effects of protease inhibitor-based and non-nucleoside reverse transcriptase inhibitor-based therapies in young men.