GENERAL CLINICAL RESEARCH CENTER M01 RR12248

Einstein-Montefiore GCRC受益于全国临床研究的增加， 来自机构投资，允许其范围和创新的扩展。我们的每日GCRC 提供平台和工具，以维持涵盖糖尿病、癫痫、衰老和 生殖生理学，镰状细胞贫血，艾滋病毒/艾滋病，心血管疾病和癌症。在本项目期间，我们 成功实施了2个最先进的核心，其中一个是高场磁共振（MR）研究核心， 第二个是提供质谱分析和其他分析的分析核心实验室。我们的培训 这些努力不仅产生了新的K12和K23研究人员，他们使用GCRC进行项目， 还将GCRC与医学院的培训使命相结合。GAC和RSA已 与IRB合作，将数据和安全监测指南付诸实践，我们已经实施了 安全研究信息管理。总的来说，GCRC经历了戏剧性的门诊访问 在过去的两年里，我们的调查人员一直很有成效;因此，目前的应用程序 包括60个项目，比我们以前的申请增加了50%，联邦总金额超过5500万美元。 研究资助。GCRC的首席研究员是Dominick Purpura，医学博士，学院院长 其项目主任是Harry Shamoon，医学博士，临床研究副院长。Drs. 罗纳德内格尔和桑吉夫古普塔将继续担任副项目主任。Jullie Pan医学博士、博士和丹尼尔 Stein，MD分别是MR和Analytic Cores的董事，Hillel Cohen，DrPH继续担任 GCRC生物统计学家。Margaret Arnim，MBA是行政总监。由于我们的成功， 为了支持临床研究，研究机构正在完成第二个门诊GCRC设施， 实验室毗邻新的儿童医院在蒙蒂菲奥里，这将增加容量，并提供一个 （迄今为止不可用）儿科临床研究的网站。GCRC是该机构的协调中心， 临床和转化研究的战略计划，包括建设一个2亿美元的遗传学中心 和转化医学，招募临床研究人员，开发创新研究培训和职业生涯 发展，促进新的科学努力。根据我们的记录，我们希望这个应用程序 证明我们的GCRC值得进一步投资。随着中心的发展，我们要求 支持扩大领导层，包括儿科副项目主任（弗雷德里克·卡斯科尔 医学博士，博士），研究培训（Paul Marantz医学博士，公共卫生硕士），神经学（Shlomo Shinnar医学博士，博士），以及 增加人员和资源，以实现这一急需的扩张。

The Einstein-Montefiore GCRC has benefited from the augmentation of clinical research nationally as well as from Institutional investments that have permitted expansion in its scope and innovation. Our per diem GCRC provides platforms and tools to sustain a diverse portfolio of research spanning diabetes, epilepsy, aging, and reproductive physiology, to sickle cell anemia, HIV/AIDS, CVD, and cancer. In our current project period, we successfully implemented 2 state-of-the-art Cores, one a high-field Magnetic Resonance (MR) Research Core, and the second an Analytic Core Laboratory providing mass spectrometry and other analyses. Our training efforts have not only yielded new K12 and K23 investigators who use the GCRC for their projects, but have also integrated the GCRC with the training mission of the College of Medicine. The GAC and the RSA have collaborated with the IRBs to put data and safety monitoring guidelines into practice, and we have implemented secure research informatics management. In the aggregate, the GCRC has experienced dramatic outpatient visit increases in the past two years, and our investigators have been highly productive; thus, the current application includes 60 projects, -50% more than in our previous application with a total of over $55 million in Federal research grant support. The Principal Investigator of the GCRC is Dominick Purpura, MD, Dean of the College of Medicine, and its Program Director is Harry Shamoon, MD, Associate Dean for Clinical Research. Drs. Ronald Nagel and Sanjeev Gupta will continue as Associate Program Directors. Jullie Pan MD, PhD and Daniel Stein, MD are directors of the MR and the Analytic Cores, respectively, and Hillel Cohen, DrPH continues as GCRC Biostatistician. Margaret Arnim, MBA is the Administrative Director. Owing to the success of our GCRC in supporting clinical investigation, the Institution is completing a second outpatient GCRC facility and laboratory adjacent to the new Children's Hospital at Montefiore that will increase capacity and provide a (heretofore unavailable) site for pediatric clinical research. The GCRC is at the focal point of the Institution's Strategic Plan for clinical and translational research that includes constructing a $200-million Center for Genetic and Translational Medicine, recruiting clinical investigators, developing innovative research training and career development, and facilitating new scientific endeavors. Based on our track record, we hope this application demonstrates that our GCRC merits further investment. In keeping with growth of the Center, we request support for an expanded leadership including Associate Program Directors for Pediatrics (Frederick Kaskel MD,PhD), Research Training (Paul Marantz MD,MPH), and Neurology (Shlomo Shinnar MD,PhD), and also for the additional personnel and resources to enable this much-needed expansion.