Mitochondrial Energy Metabolism and Insulin Action

肥胖和2型糖尿病是与能量代谢异常相关的两种主要健康状况。在本提案中，我将研究重要的代谢蛋白在调节骨骼肌和脂肪组织的能量消耗和胰岛素作用中的作用，骨骼肌和脂肪组织是整个身体能量代谢的两个关键组织。这些研究将对导致肥胖和2型糖尿病的因素提供关键的见解，并将有助于确定可能的治疗靶点。

Obesity and type 2 diabetes are two major health conditions associated with abnormal energy metabolism. In this proposal I will investigate the role of important metabolic proteins in regulating energy expenditure and insulin action in skeletal muscle and adipose tissue, two crucial tissues for whole-body energy metabolism. These studies will provide critical insight into the factors leading to obesity and type 2 diabetes and will assist in identifying possible therapeutic targets.