Radiofrequency Tumor Ablation at Low Frequencies

描述（由申请人提供）射频（RF）消融是一种有前途的微创热基方法，用于消融肝癌、肾癌、骨癌和肺癌。在成像引导下，将电极插入肿瘤中，并向电极施加射频电流，从而导致离子搅动和组织加热。一旦温度超过50摄氏度，肿瘤就会被凝固性坏死破坏。射频消融的主要优点之一是它可以以微创方式应用，从而使患者恢复迅速，发病率低。由于历史原因，商业射频消融器械在450 - 500 kHz的频率范围内工作。我们之前已经在计算模型中表明，较低频率范围（~10 kHz）的射频消融可能会优先加热肿瘤组织。在这个建议中，我们将验证这个假设的优先加热癌症在较低的频率。我们将测量人体肿瘤组织的电组织特性数据，使用这些数据在计算机模型中比较低频标准射频消融，并最终确认体外研究中低频射频消融的益处。该项目的成功完成可能会导致更有效的癌症治疗，这将提供优先加热和杀死癌症，并保留正常组织。

DESCRIPTION (provided by applicant) Radiofrequency (RF) ablation is a promising, minimally invasive heat-based method used to ablate cancer of the liver, kidney, bone, and lung. Under imaging guidance, an electrode is inserted into the tumor, and radiofrequency current is applied to the electrode resulting in ionic agitation and tissue heating. The tumor is destroyed by coagulative necrosis once it reaches temperatures above 50 degrees C. One of the major advantages of RF ablation is that it can be applied in a minimally invasive fashion, resulting in rapid patient recovery and low morbidity. Due to historic reasons, commercial RF ablation devices operate in the frequency range of 450 - 500 kHz. We have previously shown in computational models that RF ablation in a lower frequency range (~10 kHz) may preferentially heat tumor tissue. In this proposal we will validate this hypothesis of preferential heating of cancer at lower frequencies. We will measure data on electrical tissue properties of human tumor tissue, use these data to compare RF ablation at standard at low frequencies in computer models, and finally confirm benefits of low-frequency RF ablation in ex vivo studies. PUBLIC HEALTH RELEVANCE Successful completion of this project may result in a more effective treatment of cancer that will provide preferential heating and kill of cancer and sparing of normal tissue.