ROLE OF ANTIMICROBIAL PEPTIDES IN HOST DEFENSE AGAINST VACCINIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究涉及对特应性皮炎、哮喘、银屑病患者和正常对照组的血细胞和皮肤进行分析，以确定特应性皮炎患者发生牛痘性湿疹的风险增加的原因。 接种天花疫苗后会出现严重的危及生命的皮疹。 它不发生在银屑病、哮喘或正常对照患者中。 因此，我们希望比较银屑病、哮喘患者或正常对照与特应性皮炎患者的血细胞和皮肤活检对天花疫苗的反应。 将血细胞和皮肤活检暴露于天花疫苗仅在实验室进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study involves an analysis of blood cells and skin from patients with atopic dermatitis, asthma, psoriasis, and normal controls to determine why patients with atopic dermatitis are at increased risk for developing eczema vaccinatum. Eczema vaccinatum is a severe life-threatening rash that can result from smallpox vaccination. It does not occur in patients with psoriasis, asthma, or normal controls. Thus, we wish to compare responses of blood cells and skin biopsies from patients with psoriasis, asthma, or normal controls to patients with atopic dermatitis to the smallpox vaccine. Exposure of blood cells and skin biopsies to smallpox vaccine will be done exclusively in the laboratory.