MECHANISMS DEFENDING FAT MASS IN HUMANS AFTER LIPECTOMY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 没有人能肯定吸脂手术去除的脂肪是永久性的。本研究的目的就是回答这个问题。我们将探讨基因和新陈代谢对吸脂术去除脂肪的影响的可能性。脂肪活组织检查将在吸脂前进行，并在吸脂后再进行两次，以确定哪些基因被表达，以及它们的表达如何预测和/或与吸脂部位和身体其他部位的体脂变化有关。两组受试者将参加。第一组将在抽脂前和抽脂后3年内进行检查，而第二组将在3年内进行类似的测量，但不进行抽脂。然而，在研究期间没有接受吸脂术的那组受试者将有机会在3年后以较低的成本进行吸脂术。这项研究将有助于回答一个关于常见整容手术的重要问题，该手术可能会为人体脂肪是如何调节的提供更多的见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. No one is sure that the fat removed by liposuction is permanent. The purpose of this study is to answer this question. We will explore the possibility that genetics and metabolism contribute to the response of fat removal by liposuction. Fat biopsies will be carried out before and twice more after liposuction to determine what genes are expressed and how their expression predicts and/or relates to changes in body fat at the liposuction site and elsewhere in the body. Two groups of subjects will participate. The first group will be examined before and up to 3 years after liposuction, whereas the second group will have similar measurements over 3 years but no liposuction. However, the group of subjects who do not receive liposuction during the study period will have an opportunity to have liposuction performed after 3 years at a reduced cost. This study will help to answer an important question about a common cosmetic surgery that may provide additional insights into how body fat is regulated in humans.