METABOLIC AND PHYSIOLOGIC STABILITY FOLLOWING WEIGHT LOSS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究将确定体重减轻后代谢率恢复正常需要多长时间。当人们减肥时，他们的代谢率会降低，但一段时间后，代谢率似乎会恢复正常，尽管这个问题仍然存在争议。在这项研究中，我们将在减肥10%的目标实现后的最初几周内多次测量代谢率。在接下来的3个月里，受试者将继续接受GCRC营养师的监督，在此期间，我们将帮助他们保持体重减轻，并每隔1个月测量一次代谢率。这将帮助我们回答代谢率是否仍然低迷，如果不是，需要多长时间才能恢复正常的问题。我们还将在此期间测量血液中选定的荷尔蒙、蛋白质和血脂，以确定这些变量中的任何一个在长期减肥维持期间是否发生变化。我们将要求受试者在一年后返回并重复实验，我们还将测量他们的体重。然后，我们将看看我们在减肥维持的早期阶段获得的任何测量结果是否可以预测体重恢复的程度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will determine how it long it takes for metabolic rate to return to normal after weight loss. When people lose weight, their metabolic rate is reduced, but after some time, it appears to return to normal, although this issue is still debated. In this study, we will measure metabolic rate several times during the first few weeks after a target of 10% weight loss has been achieved. Subjects will remain under supervision of the GCRC dietitians for the next 3 months, and during this period, we will help them maintain their weight loss and measure metabolic rate at 1 month intervals. This will help us answer the question of whether metabolic rate remains depressed, and if not, how long it takes to return to normal. We will also measure selected hormones, proteins, and lipids in the blood during this period to determine if any of these variables are altered during the prolonged period of weight loss maintenance. We will ask subjects to return 1 year later and repeat the experiment, and we will also measure their body weight. We will then look to see if any of the measurements we obtained during the early portion of weight-loss maintenance predict how much weight is regained.