KAINIC ACID DERIVATIVES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 博士Choony将开发一个独立的研究计划，使用空间支撑来制造红藻氨酸。 红藻氨酸及其衍生物是有效的GABA模拟物，显示出作为神经兴奋剂、杀虫剂和抗蠕虫剂的生物活性。 红藻氨酸衍生物作用于多巴胺能和GABA突触。 注射海人素后的神经元细胞死亡已被提出作为在老年性痴呆中观察到的神经元细胞损失的重要模型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Choony will be developing an independent research program in the use of steric buttresses to make kainic acid. Kainic acid and its derivatives are potent GABA-mimetics, showing bioactivity as neuroexcitatory agents, insecticides, and antihelminthics. Kainic acid derivatives act on both glutaminergic and GABA synapses. Neuronal cell death following injection of kainoids has been proposed as an important model for the neuronal cell loss observed in senile dementia.