EVALUATION OF BONE MASS AND STRENGTH IN PEDIATRIC POPULATIONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 外周定量计算机断层扫描（pQCT）提供了真实体积骨矿物质密度和骨强度的测量，并能够分离骨小梁和皮质骨室。关于儿童和年轻人的pQCT测量数据有限。因此，本研究的目的是在儿科人群中开发规范性pQCT数据，用于以下临床研究：正常骨生长和发育、生长和发育期间肌肉与骨强度关系的变化、慢性疾病/疾病对骨健康的影响的评估以及改善弱势人群骨健康的干预试验的开发。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Peripheral quantitative computed tomography (pQCT) provides a measurement of true volumetric bone mineral density and bone strength and is able to separate trabecular and cortical bone compartments. Only limited data is available on pQCT measurements in children and young adults. Therefore, the purpose of this study is to develop normative pQCT data in pediatric populations for use in clinical studies of: normal bone growth and development, changes in the relationship of muscle to bone strength during growth and development, the assessment of the effect of chronic illness/disease on bone health, and the development of intervention trials to improve bone health in vulnerable populations.