FMRI OF ALCOHOL-INDUCED URGE TO SMOKE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 虽然饮酒和吸烟是高度相关的成瘾行为，但人们对酒精诱导的吸烟欲望所涉及的大脑活动知之甚少。 因此，这项初步研究的目的是利用功能性磁共振成像（fMRI），以辨别大脑区域激活酒精在视觉吸烟线索的存在。 据预测，与安慰剂饮料相比，酒精会特别激活已被其他滥用药物激活的区域，包括中脑边缘多巴胺、前额叶皮层和与视觉空间注意力相关的区域。 目标是入组n=14例（7例男性和7例女性）习惯性饮酒-吸烟受试者。 将在芝加哥大学脑研究成像中心（BRIC）的3.0特斯拉GE Signa系统（密尔沃基，WI）上进行扫描。 受试者将在饮酒前基线和功能磁共振成像扫描期间，在中性和吸烟相关视觉线索呈现之前和之后完成标准化的香烟渴望量表。 根据PI及其同事的几项研究，在血液酒精水平上升和预期吸烟欲望峰值增加期间，将获得高分辨率功能成像。 这些数据将提供有关酒精增加吸烟欲望的大脑活动的信息。这项研究的最终目标是帮助有针对性的治疗和预防工作，以减少同时大量使用这两种物质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While drinking and smoking are highly associated addictive behaviors, little is known about brain activity involved in alcohol-induced desire to smoke. Therefore, this pilot study aims to utilize functional magnetic resonance imaging (fMRI) in order to discern brain regions activated by alcohol in the presence of visual smoking cues. It is predicted that areas that have been shown to be activated by other drugs of abuse, including mesolimbic dopamine, prefrontal cortex, and areas related to visuospatial attention will be particularly activated after alcohol compared to placebo beverage. The goal will be to enroll n=14 (7 male and 7 female) habitual drinker-smoker participants. Scanning will be performed at the University of Chicago Brain Research Imaging Center (BRIC) on a 3.0 Tesla GE Signa System (Milwaukee, WI). Subjects will complete standardized scales of cigarette craving at pre-drink baseline and during fMRI scanning, before and after presentation of both neutral and smoking-related visual cues. High resolution functional imaging will be obtained during the interval when blood alcohol levels are rising and peak increases in smoking urges are expected, based on several studies by the PI and her colleagues. The data will provide information on brain activity underlying cigarette craving increased by alcohol. The ultimate goal of this research is to help target treatment and prevention efforts to reduce concurrent heavy use of both substances.