A FAMILY STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的第一个目的是确定间歇性爆炸性疾病（IED）是否在家庭中流行。 IED是一种以频繁和突然爆发的愤怒而闻名的疾病，导致与其他人在社交或工作中出现问题。 第二个目的是看看IED的历史是否与血清素（一种被认为与愤怒有关的化学物质）功能的差异有关，这是通过对血小板的研究和/或通过检查血液样本中的DNA可以检测到的某些基因的变异来测量的。 本研究将涉及100例IED受试者（先证者）及其一级亲属，以及100例对照受试者（健康志愿者）及其一级亲属。 我们预计每个受试者（先证者）至少有四（4）个亲属。 如果你同意参加这项研究，你将接受一系列的诊断访谈，提供一小部分血液样本用于血小板和DNA测试（这项测试着眼于大脑化学的各个方面），完成几份关于你成长过程中的情绪、行为和家庭生活回忆的纸笔问卷，并完成几组计算机任务。 总的来说，这些程序将需要大约八到十（8-10）小时的时间。 这些程序可以在你方便的时候分散在两天或两天以上。 最后，我们将要求您帮助我们联系您的直系亲属，以便您也参与本研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The first purpose of this study is to determine if Intermittent Explosive Disorder (IED) runs in families. IED is a disorder notable for frequent and sudden outbursts of anger that leads to problems with other people socially or at work. A second purpose is to see if a history of IED is related to differences in the function of serotonin (a chemical which is thought to be involved in anger) as measured through studies on blood platelets and/or in variations in certain genes that can be detected by examining DNA in blood samples. This study will involve 100 Subjects (Probands) with IED and first-degree relatives of these subjects as well as 100 Control Subjects (Healthy Volunteers) and their first-degree relatives. We expect at least four (4) relatives per subject (proband). If you agree to take part in this study you will undergo a series of diagnostic interviews, give a small sample of blood for platelets and for DNA testing (this testing looks at aspects of brain chemistry), complete several paper and pencil questionnaires about your moods, behavior, and recollections of family life while you were growing up, and complete several sets of computer tasks. Overall, these procedures will take about eight to ten (8-10) hours of your time. These procedures can be spread out over two or more days at your convenience. Finally, you will be asked to help us in contacting members of your immediate family to take part in this study as well.