DOPAMINE/RESTLESS LEG SYNDROME

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 不宁腿综合症(RLS)是一种神经系统疾病，据报道，影响到2%-5%的人口。RLS是一种对多巴胺治疗有反应的感觉-运动障碍。RLS的患病率始终高于缺铁、妊娠和终末期肾病的人群患病率。尽管RLS的病理生理学机制尚不清楚，但有证据表明，多巴胺(DA)系统在脑铁缺乏中发挥了作用。我们建议测试RLS症状是对多巴胺能活动昼夜幅度增加的补偿结果。我们认为，系统在其昼夜周期中存在动态变化，而不仅仅是夜间多巴胺的单个时间段的减少。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Restless Legs Syndrome (RLS) is a neurological disorder that is reported to effect between 2-5% of the population. RLS is a sensory-motor disorder that respond to dopamine treatment. RLS prevalence is consistently higher that the population prevalence for iron deficiency, pregnancy, and end-stage renal disease. Although the pathophysiology of RLS remains unknown, evidence does suggest a role for the dopaminergic (DA) system for brain iron deficiency. We propose to test that RLS symptoms are a result of compensation for an increase in the circadian amplitude of dopaminergic activity. We propose that there is a dynamic change in the system over its circadian cycle, not just a single time-of-day decrement in dopamine at night.