FUNCTIONAL IMAGING OF MOTOR ACTIVATION PATHWAYS IN VERBAL AND MOTOR TICS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 抽动秽语综合征（TS）是一种以频繁的运动和言语抽动为特征的疾病。 抽动的确切机制和TS的病理生理被广泛讨论，但被认为与额叶皮层下回路异常有关。 该项目的目标是通过检查抽动生成、运动反应准备和反应抑制中涉及的脑激活模式，进一步阐明该运动相关回路在TS病理生理学中的作用。 我们建议使用功能磁共振成像，以确定参与生产抽搐的大脑区域，以确定TS患者是否表现出不同的模式的运动激活（包括异常的大脑优势）与反应准备，并确定TS患者是否表现出不同的激活模式时，执行一项任务，需要反应抑制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Tourette Syndrome (TS) is a disorder characterized by frequent motor and verbal tics. The exact mechanism of tic generation and the pathophysiology of TS is widely debated but believed to be related to abnormalities within frontal lobe-subcortical circuitry. The goal of this project is to further clarify the role of this motor-related circuitry in the pathophysiology of TS by examining patterns of brain activation involved in tic generation, motor response preparation and response inhibition. We propose to use fMRI to identify brain regions involved in the production of tics, to determine if patients with TS demonstrate different patterns of motor activation (including anomalous cerebral dominance) associated with response preparation, and to determine if patients with TS demonstrate different patterns of activation when performing a task that requires response inhibition.