MR IMAGE GUIDED FOCUSED ULTRASOUND FOR TREATMENT OF LIVER AND RENAL CANCER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 批准号：5R01CA121163-03 项目启动时间：28-SEP-2006 项目结束：2010年7月31日 该项目的长期目标是开发一种治疗上腹部癌症的微创疗法，包括肝脏原发和转移性肿瘤，以及肾癌。该项目的具体目标是1)设计、制造和评估在磁共振引导下用于治疗肝肾肿瘤的手持式相控阵聚焦超声治疗探头，2)开发磁共振成像软件以准确绘制上腹部组织温度图，3)对系统进行初步测试和评估。聚焦超声是下一代非侵入性肿瘤治疗系统的一种很有前途的技术。利用这项技术，超声波能量被集中在身体深处的某个点上，以热消融目标组织。这可以在皮肤表面以最小的热沉积来完成，并且不需要皮肤穿孔或切开。这里提出的努力解决了在上腹部使用聚焦超声治疗的主要技术挑战。将开发将聚焦超声治疗与磁共振图像引导相结合的技术和系统，以允许将热能精确定位到目标组织。将开发通过准确的温度映射来监测热沉积的技术，以确保整个目标体积正在接受治疗，并确定血管、胆囊和横隔膜等关键结构是否保持足够的温度以避免损坏。由于上腹部的器官在呼吸过程中会移动，因此将开发出补偿运动的MRI热成像序列。新技术和系统将在模特儿上开发，并在猪动物模型上进行测试。相关性：结直肠癌是导致男性和女性癌症相关死亡的第三大原因。这些死亡中的许多与结直肠癌转移到肝脏有关。同样，肾细胞癌是一种经常致命的恶性肿瘤，在美国的发病率正在上升。微创热疗在这些疾病的治疗中显示出良好的效果，但仍然存在许多技术挑战。这里提出的工作解决了这些挑战，如果成功，将代表着癌症非侵入性治疗方面的重大进步。 少年派：金巴茨-保利 院校：斯坦福大学，加利福尼亚州斯坦福94305

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Grant Number: 5R01CA121163-03 Project Start: 28-SEP-2006 Project End: 31-JUL-2010 The long-term goal of this project is to develop a minimally invasive treatment for cancers in the upper abdomen, including primary and metastatic tumors in the liver, and renal cell carcinoma. Specific aims of the project are to 1) design, fabricate, and evaluate handheld phased array focused ultrasound therapy probes for treating liver and renal tumors under MR guidance, 2) develop MRI imaging software to accurately map the tissue temperature in the upper abdomen, and 3) perform initial testing and evaluation of the system. Focused ultrasound is a promising technique for the next generation of non-invasive cancer therapy systems. With this technology, ultrasound energy is focused at a point deep within the body to thermally ablate targeted tissue. This can be done with minimal heat deposition at the skin surface and without skin puncture or incision. The effort proposed here addresses the main technical challenges to using focused ultrasound therapy in the upper abdomen. Techniques and systems will be developed to couple focused ultrasound treatment with Magnetic Resonance image guidance to allow precise targeting of the thermal energy to target tissues. Techniques to monitor heat deposition through accurate temperature mapping will be developed to insure that the entire target volume is being treated, and to determine if critical structures such as vessels, the gall bladder and the diaphragm remain sufficiently cool to avoid damage. Since organs in the upper abdomen move during breathing, MRI thermal imaging sequences that compensate for motion will be developed. The new techniques and systems will be developed on phantoms and tested in porcine animal models. Relevance: Colorectal cancer is the third leading cause of cancer related deaths in men and women. Many of these deaths are associated with colorectal metastases to the liver. Similarly, renal cell carcinoma is an often fatal malignancy which is increasing in incidence in the US. Minimally invasive thermal therapies are showing promising results in the treatment of these conditions, but many technical challenges remain. The work proposed here addresses these challenges and if successful, will represent a major advance in the non-invasive treatment of cancer. PI: Kim Butts-Pauly Institution: STANFORD UNIVERSITY, STANFORD, CA 94305